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PE 154 - ≥97%(HPLC), high purity , CAS No.1192750-33-6

COA

Grade & Purity:

≥97%(HPLC)

Cas Number: 1192750-33-6
Molecular Weight: 589.68
PubChem CID: 135870290
PubChem SID: 504773447

In stock

Item Number

P287589

Grouped product items
SKU	Size	Availability	Price
P287589-5mg	5mg	7	$231.90
P287589-10mg	10mg	5	$375.90
P287589-25mg	25mg	4	$751.90
P287589-50mg	50mg	4	$1,206.90

Targets and labels βamyloid plaques in histochemical analysis

View related series

Cholinesterase (ChE) (151) Neuronal Signaling (3320)

Basic Description

Synonyms	(1Z,N'E)-2-(4-(((E)-(7-(diethylamino)-2,4-dioxochroman-3-ylidene)methyl)amino)phenyl)-N'-(1,2,3,4-tetrahydroacridin-9(10H)-ylidene)acetohydrazonic acid \| 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50values are 280 pM and 16 nM respectively). Targets and labelsβ-amyloid plaques in histochemical analysis.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Product description： PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively)[1]. PE154 can label β-amyloid plaques in histochemical analysis.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Benzoquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Benzoquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Acridines
Alternative Parents	4-hydroxycoumarins Phenylacetamides 1-benzopyrans Polyhalopyridines Dialkylarylamines Pyranones and derivatives Methylpyridines Fatty acid esters 2-halopyridines Vinylogous acids Secondary ketimines Heteroaromatic compounds Enol esters Enoate esters Trialkylamines Lactones Amino acids and derivatives Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Enamines Azacyclic compounds Aldimines Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Acridine - Hydroxycoumarin - 4-hydroxycoumarin - Coumarin - 1-benzopyran - Phenylacetamide - Benzopyran - Polyhalopyridine - Dialkylarylamine - Tertiary aliphatic/aromatic amine - 2-halopyridine - Methylpyridine - Pyranone - Fatty acid ester - Fatty acyl - Benzenoid - Pyridine - Pyran - Monocyclic benzene moiety - Heteroaromatic compound - Vinylogous acid - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Secondary ketimine - Enol ester - Tertiary aliphatic amine - Tertiary amine - Lactone - Ketimine - Carboxylic acid ester - Amino acid or derivatives - Oxacycle - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Enamine - Carboxylic acid derivative - Aldimine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Imine - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504773447
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773447
IUPAC Name	2-[4-[[7-(diethylamino)-4-hydroxy-2-oxochromen-3-yl]methylideneamino]phenyl]-N'-(1,2,3,4-tetrahydroacridin-9-yl)acetohydrazide
INCHI	InChI=1S/C35H35N5O4/c1-3-40(4-2)24-17-18-27-31(20-24)44-35(43)28(34(27)42)21-36-23-15-13-22(14-16-23)19-32(41)38-39-33-25-9-5-7-11-29(25)37-30-12-8-6-10-26(30)33/h5,7,9,11,13-18,20-21,42H,3-4,6,8,10,12,19H2,1-2H3,(H,37,39)(H,38,41)
InChIKey	RSKDYQUBLFFWPM-UHFFFAOYSA-N
Smiles	CCN(CC)C1=CC2=C(C=C1)C(=C(C(=O)O2)C=NC3=CC=C(C=C3)CC(=O)NNC4=C5CCCCC5=NC6=CC=CC=C64)O
WGK Germany	3
PubChem CID	135870290
Molecular Weight	589.68

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
G2311813	Certificate of Analysis	May 25, 2023	P287589
G2311810	Certificate of Analysis	May 25, 2023	P287589
G2311814	Certificate of Analysis	May 25, 2023	P287589
G2311801	Certificate of Analysis	May 25, 2023	P287589
G2311807	Certificate of Analysis	May 25, 2023	P287589
G2311818	Certificate of Analysis	May 25, 2023	P287589
G2311811	Certificate of Analysis	May 25, 2023	P287589
G2311808	Certificate of Analysis	May 25, 2023	P287589

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 29.48, Max Conc. mM: 50
Molecular Weight	589.700 g/mol
XLogP3	6.200
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	589.269 Da
Monoisotopic Mass	589.269 Da
Topological Polar Surface Area	116.000 Å²
Heavy Atom Count	44
Formal Charge	0
Complexity	1070.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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