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PBOX 6 - 99%, high purity , CAS No.290814-68-5

Grade & Purity:

≥99%

Cas Number: 290814-68-5
Molecular Weight: 396.44
PubChem CID: 9865511

In stock

Item Number

P648174

Grouped product items
SKU	Size	Availability	Price
P648174-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$160.90
P648174-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
P648174-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$410.90
P648174-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$615.90
P648174-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$955.90

View related series

Apoptosis (4276) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Cytoskeleton (498) Microtubule/Tubulin (199)

Synonyms	PBOX-6 \| CS-0035400 \| 7-[(N,N-dimethylcarbamoyl)oxy]-6-(naphth-1-yl)pyrrolo[2,1-d][1,5]benzoxazepine \| MS-26682 \| HY-U00446 \| Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo(2,1-d)(1,5)benzoxazepin-7-yl ester \| AKOS040742367 \| PBOX 6 \| pyrrolo-1,5
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule -depolymerizing agent and an apoptotic agent.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule -depolymerizing agent and an apoptotic agent. In Vitro PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells. PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Apoptosis, Microtubule

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzoxazepines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Benzoxazepines
Alternative Parents	Naphthalenes Pyrroles Heteroaromatic compounds Enol esters Carbamate esters Oxacyclic compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzoxazepine - Naphthalene - Benzenoid - Enol ester - Pyrrole - Carbamic acid ester - Heteroaromatic compound - Azacycle - Oxacycle - Organic oxide - Carbonyl group - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as benzoxazepines. These are organic compounds containing a benzene fused to an oxazepine ring (a seven-membered ring with four carbon atoms, one oxygen atom, and a nitrogen atom).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

IUPAC Name	(6-naphthalen-1-ylpyrrolo[2,1-d][1,5]benzoxazepin-7-yl) N,N-dimethylcarbamate
INCHI	InChI=1S/C25H20N2O3/c1-26(2)25(28)30-24-21-14-8-16-27(21)20-13-5-6-15-22(20)29-23(24)19-12-7-10-17-9-3-4-11-18(17)19/h3-16H,1-2H3
InChIKey	SOIZAFVNIXAZFQ-UHFFFAOYSA-N
Smiles	CN(C)C(=O)OC1=C(OC2=CC=CC=C2N3C1=CC=C3)C4=CC=CC5=CC=CC=C54
Isomeric SMILES	CN(C)C(=O)OC1=C(OC2=CC=CC=C2N3C1=CC=C3)C4=CC=CC5=CC=CC=C54
PubChem CID	9865511
Molecular Weight	396.44

Solubility	DMSO : 33.33 mg/mL (84.07 mM; Need ultrasonic)
Molecular Weight	396.400 g/mol
XLogP3	4.800
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	396.147 Da
Monoisotopic Mass	396.147 Da
Topological Polar Surface Area	43.700 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	675.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

PBOX 6 - 99%, high purity , CAS No.290814-68-5

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