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Pateclizumab (anti-TNFb) - Primary antibody, specific to LTA, >95%, high purity, Human IgG1, INHIBITOR of TNF-beta inhibitor, INHIBITOR of TNF-beta inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175626
Grouped product items
SKU Size
Availability
Price Qty
Ab175626-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab175626-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab175626-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab175626-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Pateclizumab (anti-TNFb) - Primary antibody, specific to LTA, >95%, high purity, Human IgG1, INHIBITOR of TNF-beta inhibitor
Synonyms LTalpha antibody | DAMA-25N12.13-004 antibody | DIF antibody | LT alpha antibody | LT antibody | LT-alpha antibody | Lta antibody | Lymphotoxin alpha (TNF superfamily, member 1) antibody | Lymphotoxin alpha antibody | Lymphotoxin-alpha antibody | MGC11766
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and
Host species Human
Specificity LTA
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of TNF-beta inhibitor
Product Description

Pateclizumab (anti-TNFb) is a humanized monoclonal antibody that blocks and depletes anti-lymphotoxin α (LTα). It has a great potential for the treatment of rheumatoid arthritis (RA).


Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.7 kDa (Light Chain) & 50.7 kDa (Heavy Chain), under reducing conditions; 191.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1202526-59-7

Associated Targets(Human)

LTA Tbio Lymphotoxin-alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
LTA Tbio TNF-beta (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Pateclizumab (anti-TNFb) (Ab175626) - ELISA
Immobilized huTNFSF1/TNFb-His at 2.0 μg/mL can bind Pateclizumab (anti-TNFb) (Ab175626) with the EC₅₀ of 13.51 ng/mL.

Pateclizumab (anti-TNFb) (Ab175626) - SEC
The purity of Pateclizumab (anti-TNFb) (Ab175626) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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