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Pan KRas-IN-1 - 98%, high purity , CAS No.2791263-84-6

COA

Grade & Purity:

≥98%

Cas Number: 2791263-84-6
Molecular Weight: 607.67

In stock

Item Number

P647729

Grouped product items
SKU	Size	Availability	Price
P647729-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$280.90
P647729-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$820.90
P647729-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,320.90

View related series

G Protein Related (287) GPCR/G Protein (3172) Ras (143)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors.
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors In Vitro Pan KRas-IN-1 (example 5) shows high binding capacity to KRas, with IC 50 s of <2 nM among different KRas isform, including G12D, G12V, G12R, G12A, G12S, G13D, Q61H, and WT. Pan KRas-IN-1 inhibits the phosphorylation of ERK downstream of KRas in different cells; AsPC-1 (G12D, IC 50 =9 nM), A549 (G12S, IC 50 =11 nM), HCT116 (G13D, IC 50 =23 nM), NCI-H358 (G12C, IC 50 =6 nM), NCI-H460 (Q61H, IC 50 =12 nM), NCI-H727 (G12V, IC 50 =29 nM), MKN1 (WT, IC 50 =32 nM), PSN-1 (G12R, IC 50 =681 nM). Pan KRas-IN-1 (0-3000 nM; 5 d) exhibits anti-proliferative activity against mutation of reststance to Adagrasib in mouse 3T3 fibroblasts, with IC 50 s of 32 nM (G12A), 28.1 nM (G12C), 20.25 nM (G12D), 1742 nM (G12R), 94 nM (G12V), 50 nM (G12W), 610 nM (G13D), 58 nM (Q61H). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:KRas G12D 9 nM (IC 50 ) KRas G12S 11 nM (IC 50 ) KRas G12C 6 nM (IC 50 ) KRas Q61H 12 mM (IC 50 ) KRas G12V 29 mM (IC 50 ) K-Ras WT 32 nM (IC 50 ) K-Ras G12R 681 nM (IC 50 ) K-Ras G13D 23 nM (IC 50 )

Names and Identifiers

Smiles	FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5C[C@](O)(CCC5)C)OC[C@@]67N(CCC7)C[C@@H](C6)F
Molecular Weight	607.67

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