Skip to the beginning of the images gallery

Pamidronate disodium salt hydrate - ≥97%, high purity , CAS No.57248-88-1

COA

Grade & Purity:

≥97%

Cas Number: 57248-88-1
Molecular Weight: 279.03 (anhydrous basis)
MDL number: MFCD11045314
PubChem CID: 73351
PubChem SID: 488184778

In stock

Item Number

P129944

Grouped product items
SKU	Size	Availability	Price
P129944-50mg	50mg	3	$20.90
P129944-250mg	250mg	2	$77.90
P129944-1g	1g	2	$238.90
P129944-5g	5g	2	$1,073.90
P129944-25g	25g	2	$4,828.90

Biphosphate compound able to inhibit bone resorption

View related series

Element classified compounds (2014) Phosphonic acids (146)

Basic Description

Synonyms	CGP-23339AE \| DISODIUM DIHYDROGEN (3-AMINO-1-HYDROXYPROPYLIDENE)DIPHOSPHONATE \| BCP22745 \| Nitrocardiol \| NSC720699 \| GCP-23339A \| Pamidronate sodium \| Pamidronic acid sodium salt \| CGP-23339A \| Acetic acid, (m-chlorophenoxy)- \| pamidronate disodium monoh
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Pamidronate disodium salt is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase and bone resorption. Studies suggest that Pamidronate disodium salt stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. I
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A farnesyl diphosphate synthase inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Organic phosphonic acids and derivatives
    - Subclass Bisphosphonates

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Organic phosphonic acids and derivatives
Subclass	Bisphosphonates
Intermediate Tree Nodes	Not available
Direct Parent	Bisphosphonates
Alternative Parents	Organic phosphonic acids 1,3-aminoalcohols Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic zwitterions Organic sodium salts Organic oxides Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Bisphosphonate - 1,3-aminoalcohol - Organophosphonic acid - Organic alkali metal salt - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organic sodium salt - Organic salt - Organic zwitterion - Primary amine - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Amine - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488184778
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488184778
IUPAC Name	disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate
INCHI	InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
InChIKey	CEYUIFJWVHOCPP-UHFFFAOYSA-L
Smiles	C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
Isomeric SMILES	C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
RTECS	SZ6525000
Molecular Weight	279.03 (anhydrous basis)
Reaxy-Rn	6459607
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6459607&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot Number	Certificate Type	Date	Item
B23031176	Certificate of Analysis	Nov 13, 2024	P129944
B23031042	Certificate of Analysis	Nov 13, 2024	P129944
B23031179	Certificate of Analysis	Nov 13, 2024	P129944
B23031224	Certificate of Analysis	Nov 13, 2024	P129944
B23031216	Certificate of Analysis	Nov 13, 2024	P129944
B23031178	Certificate of Analysis	Nov 13, 2024	P129944
B23031038	Certificate of Analysis	Nov 11, 2024	P129944
B23031291	Certificate of Analysis	Nov 11, 2024	P129944
C2406465	Certificate of Analysis	Mar 11, 2024	P129944
F2517268	Certificate of Analysis	Mar 11, 2024	P129944
C2406466	Certificate of Analysis	Mar 11, 2024	P129944
C2406440	Certificate of Analysis	Mar 11, 2024	P129944
C2406444	Certificate of Analysis	Mar 11, 2024	P129944
C2406445	Certificate of Analysis	Mar 11, 2024	P129944
C2406449	Certificate of Analysis	Mar 11, 2024	P129944
C2406452	Certificate of Analysis	Mar 11, 2024	P129944
C2406464	Certificate of Analysis	Mar 11, 2024	P129944
F1509099	Certificate of Analysis	Jan 05, 2023	P129944

Show more⌵

Chemical and Physical Properties

Solubility	DMSO Water 56 mg/mL Ethanol
Sensitivity	Heat Sensitive
Molecular Weight	279.030 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	278.965 Da
Monoisotopic Mass	278.965 Da
Topological Polar Surface Area	167.000 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	238.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration