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Palomid 529 (P529) - ≥98%, high purity , CAS No.914913-88-5

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
P129589
Grouped product items
SKU Size
Availability
 Price Qty
P129589-5mg
5mg
3
$58.90
P129589-10mg
10mg
2
$83.90
P129589-25mg
25mg
1
$189.90
P129589-50mg
50mg
1
$296.90
P129589-100mg
100mg
1
$494.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Apoptosis (4276) mTOR (145) PI3K/Akt/mTOR (765)

Basic Description

Synonyms 8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxyphenyl)methoxy)-6h-dibenzo(b,d)pyran-6-one | (z)-ocimene | Oroxylin A, >=98% (HPLC) | SCHEMBL290034 | SG00529 | SW219676-1 | Palomid 529 (P529) | 6-methoxy-4'-methylapigenin | RES-529 | s2238 | 8-(1-Hydroxyethyl)-
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Palomid 529 is a novel inhibitor of PI3K, Akt, and mTOR. Palomid 529 is an inhibitor of the TORC1 and TORC2 complexes and inhibits Akt signaling and mTOR signaling in similar ways in vasculature and tumor. Palomid 529 is an inhibitor of tumor growth, angi
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Palomid 529 (P529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6 but no effect observed on pMAPK or pAktT308.
A novel PI3K/Akt/mTOR inhibitor with a GI50 of <35 μM in the NCI-60 cell lines panel.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Coumarins and derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Coumarins and derivatives
Alternative Parents Isocoumarins and derivatives  2-benzopyrans  1-benzopyrans  Phenoxy compounds  Methoxybenzenes  Anisoles  Pyranones and derivatives  Alkyl aryl ethers  Heteroaromatic compounds  Secondary alcohols  Lactones  Oxacyclic compounds  Organic oxides  Hydrocarbon derivatives  Aromatic alcohols  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Coumarin - Isocoumarin - Benzopyran - 2-benzopyran - 1-benzopyran - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Alkyl aryl ether - Pyranone - Monocyclic benzene moiety - Benzenoid - Pyran - Heteroaromatic compound - Lactone - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Ether - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Alcohol - Organic oxide - Aromatic alcohol - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
External Descriptors Not available

Product Properties

ALogP 4

Associated Targets(Human)

YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488197837
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488197837
IUPAC Name 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]benzo[c]chromen-6-one
INCHI InChI=1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3
InChIKey YEAHTLOYHVWAKW-UHFFFAOYSA-N
Smiles CC(C1=CC2=C(C=C1)C3=CC(=C(C=C3OC2=O)OCC4=CC=C(C=C4)OC)OC)O
Isomeric SMILES CC(C1=CC2=C(C=C1)C3=CC(=C(C=C3OC2=O)OCC4=CC=C(C=C4)OC)OC)O
WGK Germany 3
RTECS HP8756500
Molecular Weight 406.43
Reaxy-Rn 15029869
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15029869&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
C2316359 Certificate of Analysis Dec 18, 2024 P129589
C2316357 Certificate of Analysis Dec 18, 2024 P129589
C2316342 Certificate of Analysis Dec 18, 2024 P129589
C2316336 Certificate of Analysis Dec 18, 2024 P129589
C2316334 Certificate of Analysis Dec 18, 2024 P129589
C2316358 Certificate of Analysis Dec 10, 2024 P129589
C2316326 Certificate of Analysis Dec 10, 2024 P129589
C2316355 Certificate of Analysis Dec 10, 2024 P129589
C2316339 Certificate of Analysis Dec 10, 2024 P129589
C2316354 Certificate of Analysis Dec 10, 2024 P129589

Chemical and Physical Properties

Solubility Soluble in DMSO (81 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Molecular Weight 406.400 g/mol
XLogP3 4.000
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 6
Exact Mass 406.142 Da
Monoisotopic Mass 406.142 Da
Topological Polar Surface Area 74.200 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 574.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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