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Oxcarbazepine - 10mM in DMSO, high purity , CAS No.28721-07-5(DMSO), Sodium channel alpha subunit blocker
Sodium Channel Inhibitors
Basic Description
Synonyms
GP47680 | 10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22 Na+ into rat brain synaptosomes with IC50 about 100 μM.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
BLOCKER
Mechanism of action
Sodium channel alpha subunit blocker
Product Description
Information
Oxcarbazepine Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22 Na + into rat brain synaptosomes with IC50 about 100 μM.In vitro
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥95%
Product Properties
ALogP
2.131
hba_count
2
HBD Count
1
Names and Identifiers
Smiles
NC(=O)N1C2=C(CC(=O)C3=C1C=CC=C3)C=CC=C2
Molecular Weight
252.27
Reaxy-Rn
1474055
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1474055&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
DMSO(mg / mL) Max Solubility
7
DMSO(mM) Max Solubility
27.75
Water(mg / mL) Max Solubility
<1
Citations of This Product
1.
Yuanyuan Fu, Zhentao Li, Changjun Hu, Qiaoyan Li, Zilin Chen.
(2023)
In-situ immobilization of covalent organic frameworks as stationary phase for capillary electrochromatography. JOURNAL OF CHROMATOGRAPHY A,
1705
(464205).
2.
Chunyan Hu, Jianyi Li, Juncheng Ke, Jianjun Liang, Qiuliang Liu, Qiliang Wang, Wentao Huang.
(2023)
The preparation and removal performance of carbamazepine/oxcarbazepine double template magnetic molecularly imprinted polymers. SEPARATION AND PURIFICATION TECHNOLOGY,
306
(122556).
3.
Cong Pan, Libin Fu, Fenna Lide, Yaobin Ding, Chengjun Wang, Jia Huang, Shaobin Wang.
(2022)
Insights into bromate reduction by Fe(II): Multiple radicals generation and carbamazepine oxidation. CHEMICAL ENGINEERING JOURNAL,
431
(133957).
4.
Tongcai Liu, Kai Yin, Chengbin Liu, Jinming Luo, John Crittenden, Weiqiu Zhang, Shenglian Luo, Qunying He, Yongxiu Deng, Hui Liu, Danyu Zhang.
(2018)
The role of reactive oxygen species and carbonate radical in oxcarbazepine degradation via UV, UV/H2O2: Kinetics, mechanisms and toxicity evaluation. WATER RESEARCH,
147
(204).
5.
Bu Lingjun, Zhou Shiqing, Shi Zhou, Deng Lin, Li Guangchao, Yi Qihang, Gao Naiyun.
(2016)
Degradation of oxcarbazepine by UV-activated persulfate oxidation: kinetics, mechanisms, and pathways. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,
23
(3):
(2848-2855).
6.
Shuchao Wu, Wei Xu, Qamar Subhani, Bingcheng Yang, Deying Chen, Yan Zhu, Lanjuan Li.
(2012)
Ion chromatography combined with online electrochemical derivatization and fluorescence detection for the determination of carbamazepine in human plasma. TALANTA,
101
(541).
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6 Citations