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Oxaliplatin - 99%, high purity , CAS No.61825-94-3

    Grade & Purity:
  • ≥99%
In stock
Item Number
O124003
Grouped product items
SKU Size
Availability
Price Qty
O124003-25mg
25mg
8
$21.90
O124003-100mg
100mg
≥10
$49.90
O124003-250mg
250mg
2
$83.90
O124003-500mg
500mg
1
$132.90
O124003-1g
1g
1
$219.90
O124003-5g
5g
1
$879.90

Platinum anticancer agent. Induces DNA cross-linking.

Basic Description

Synonyms (trans-1,2-Cyclohexanediamine)oxalatoplatinu | [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum | L-OHP
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin forms platinum-DNA ad
Storage Temp Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.


Application:

Oxaliplatin has been used:as a chemotherapeutic agent in colon rectal adenocarcinoma SW480 cells by cell viability assay;for monitoring cell survival in hepatocellular carcinoma HepG2 and HepG2/R cells by MTT assay;to determine the growth inhibitory effect on human breast adenocarcinoma MDA-MB-231 cells.



Product class
hAPIs, Metal based hAPIs


Chemical properties

Chemical formula

C8H14N2O4Pt

Empirical formula

[Pt((R,R)-dach)(ox)]

Molecular weight

397.28

Metal

Pt

Theoretical metal content

49

Physical state

powder

Color

white

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic nitrogen compounds
Class Organonitrogen compounds
Subclass Cyclohexylamines
Intermediate Tree Nodes Not available
Direct Parent Cyclohexylamines
Alternative Parents Dicarboxylic acids and derivatives  Organic transition metal salts  Carboxylic acids  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Not available
Substituents Cyclohexylamine - Dicarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Organic transition metal salt - Amine - Organic salt - Primary amine - Organooxygen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as cyclohexylamines. These are organic compounds containing a cyclohexylamine moiety, which consist of a cyclohexane ring attached to an amine group.
External Descriptors platinum coordination entity

Names and Identifiers

Pubchem Sid 488196399
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196399
INCHI 1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
InChIKey ZROHGHOFXNOHSO-BNTLRKBRSA-L
Smiles C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]
Isomeric SMILES C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]
WGK Germany 3
RTECS TP2275850
Molecular Weight 397.29
Reaxy-Rn 14621501

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

45 results found

Lot Number Certificate Type Date Item
E2514581 Certificate of Analysis Mar 28, 2025 O124003
E2514584 Certificate of Analysis Mar 28, 2025 O124003
E2514585 Certificate of Analysis Mar 28, 2025 O124003
E2514597 Certificate of Analysis Mar 28, 2025 O124003
E2514582 Certificate of Analysis Mar 28, 2025 O124003
E2514583 Certificate of Analysis Mar 28, 2025 O124003
I2426284 Certificate of Analysis Aug 19, 2024 O124003
I2426286 Certificate of Analysis Aug 19, 2024 O124003
I2426287 Certificate of Analysis Aug 19, 2024 O124003
I2426288 Certificate of Analysis Aug 19, 2024 O124003
I2426289 Certificate of Analysis Aug 19, 2024 O124003
E2409315 Certificate of Analysis Apr 24, 2024 O124003
E2409316 Certificate of Analysis Apr 24, 2024 O124003
E2409317 Certificate of Analysis Apr 24, 2024 O124003
E2409318 Certificate of Analysis Apr 24, 2024 O124003
E2409319 Certificate of Analysis Apr 24, 2024 O124003
E2409320 Certificate of Analysis Apr 24, 2024 O124003
G2425020 Certificate of Analysis Apr 24, 2024 O124003
G2310622 Certificate of Analysis Jun 19, 2023 O124003
G2310625 Certificate of Analysis Jun 19, 2023 O124003
G2310615 Certificate of Analysis Jun 19, 2023 O124003
G2310612 Certificate of Analysis Jun 19, 2023 O124003
G2310610 Certificate of Analysis Jun 19, 2023 O124003
G2310607 Certificate of Analysis Jun 19, 2023 O124003
C2316151 Certificate of Analysis Mar 08, 2023 O124003
C2316152 Certificate of Analysis Mar 08, 2023 O124003
C2316100 Certificate of Analysis Mar 08, 2023 O124003
C2316175 Certificate of Analysis Mar 08, 2023 O124003
C2316101 Certificate of Analysis Mar 08, 2023 O124003
C2316105 Certificate of Analysis Mar 08, 2023 O124003
C2316136 Certificate of Analysis Mar 08, 2023 O124003
C2316106 Certificate of Analysis Mar 08, 2023 O124003
C2316153 Certificate of Analysis Mar 08, 2023 O124003
C2316108 Certificate of Analysis Mar 08, 2023 O124003
J2231099 Certificate of Analysis Jul 21, 2022 O124003
H2202519 Certificate of Analysis Jul 21, 2022 O124003
H2202550 Certificate of Analysis Jul 21, 2022 O124003
H2202598 Certificate of Analysis Jul 21, 2022 O124003
H2202559 Certificate of Analysis Jul 21, 2022 O124003
H2202585 Certificate of Analysis Jul 21, 2022 O124003
C2222376 Certificate of Analysis Feb 18, 2022 O124003
C2222546 Certificate of Analysis Feb 18, 2022 O124003
C2222377 Certificate of Analysis Feb 18, 2022 O124003
C2222513 Certificate of Analysis Feb 18, 2022 O124003
C2222440 Certificate of Analysis Feb 18, 2022 O124003

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Chemical and Physical Properties

Solubility DMSO:DMSO inactivates the activity of Oxaliplatin;H2O:Sonification and heating to 60℃ are recommended;DMF:Sonification is recommended;
Sensitivity Heat Sensitive;Moisture sensitive;Light sensitive
Molecular Weight 397.290 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 0
Exact Mass 397.06 Da
Monoisotopic Mass 397.06 Da
Topological Polar Surface Area 76.600 Ų
Heavy Atom Count 15
Formal Charge 0
Complexity 191.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 3

Citations of This Product

1. Shilin Zhou, Yuxuan Sun, Kaidi Wang, Xintao Gao, Kehong Dong, Jing Wang, Xiaochen Wu, Chuanlong Guo.  (2024)  Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.  FOOD AND CHEMICAL TOXICOLOGY,  184  (114427). 
2. Chenyi Gao, Kunpeng Jia, Jun Fang, Xuan Zhu, Jianming Hu, Yi Zhang, Jinxin Jiang, Xiuyan Yu, Danting Wang, Haochen Gu, Zhigang Chen.  (2023)  CD95 promotes stemness of colorectal cancer cells by lncRNA MALAT1.  LIFE SCIENCES,    (122394). 
3. Shufen Zhang, Yingping Zeng, Kai Wang, Guangtao Song, Yiru Yu, Tingting Meng, Hong Yuan, Fuqiang Hu.  (2023)  Chitosan-based nano-micelles for potential anti-tumor immunotherapy: Synergistic effect of cGAS-STING signaling pathway activation and tumor antigen absorption.  CARBOHYDRATE POLYMERS,    (121346). 
4. Ting Li, Wei Lu, Hui Tian, Yu Cao, Qianqian He, Xia Chen, Hailong Wang.  (2023)  Identification and Characterization of DNA–Oxaliplatin Adducts through α-hemolysin Nanopores.  ANALYTICAL CHEMISTRY,     
5. Yudi Ma, Xiaohui Lai, Zhongling Wen, Ziling Zhou, Minkai Yang, Qingqing Chen, Xuan Wang, Feng Mei, Liu Yang, Tongming Yin, Shucun Sun, Guihua Lu, Jinliang Qi, Hongyan Lin, Hongwei Han, Yonghua Yang.  (2023)  Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment.  BIOORGANIC CHEMISTRY,  139  (106703). 
6. Yuehong Zhang, Xuelin Huang, Wen-Jun Xin, Shilang He, Jie Deng, Xiangcai Ruan.  (2023)  Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice.  JOURNAL OF PAIN,  24  (1020). 
7. Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zhao.  (2023)  IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway.  BIOLOGICAL & PHARMACEUTICAL BULLETIN,  46  (1): (26-34). 
8. Yuzhu Cao, Yawen Xia, Yufei Wang, Hang Shi, Yuanyuan Wu, Yin Lu.  (2023)  MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells.  Journal of Clinical and Translational Hepatology,  11  (3): ( 584–594). 
9. Zhi-Bin Dong, Yu-Jia Wang, Meng-Lin Cheng, Bo-Jun Wang, Hong Lu, Hai-Li Zhu, Ling Liu, Min Xie.  (2022)  2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction.  PLoS One,  17  (10): (e0275428). 
10. He-Yu Yang, Ji Wu, Hong Lu, Meng-Lin Cheng, Bang-Hua Wang, Hai-Li Zhu, Ling Liu, Min Xie.  (2022)  Emodin suppresses oxaliplatin-induced neuropathic pain by inhibiting COX2/NF-κB mediated spinal inflammation.  JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,  37  (1): (e23229). 
11. Zhi-Bin Dong, Yu-Jia Wang, Wen-Jun Wan, Ji Wu, Bo-Jun Wang, Hai-Li Zhu, Min Xie, Ling Liu.  (2022)  Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats.  Experimental and Therapeutic Medicine,  24  (3): (1-10). 
12. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang.  (2022)  Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (12): (6597). 
13. Jing Deng, Anhong Cai, Xiao Ling, Qian Sun, Tianxin Zhu, Qingsong Li, Xueyan Li, Weizhu Chen.  (2023)  Comparison of UV and UV-LED activated sodium percarbonate for the degradation of O-desmethylvenlafaxine.  Journal of Environmental Sciences,  126  (656). 
14. Qingwen Xu, Yuxi Liu, Wen Sun, Tiantian Song, Xintong Jiang, Kui Zeng, Su Zeng, Lu Chen, Lushan Yu.  (2022)  Blockade LAT1 Mediates Methionine Metabolism to Overcome Oxaliplatin Resistance under Hypoxia in Renal Cell Carcinoma.  Cancers,  14  (10): (2551). 
15. Yuzhu Cao, Keqin Lu, Yawen Xia, Yufei Wang, Aiyun Wang, Yang Zhao.  (2022)  Danshensu Attenuated Epithelial-Mesenchymal Transformation and Chemoresistance of Colon Cancer Cells Induced by Platelets.  Frontiers in Bioscience-Landmark,  27  (5): (160). 
16. Zhipeng Jiang, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen.  (2022)  Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance.  Bioengineered,  13  (1): (810-823). 
17. Yuting Shen, Liang Chen, Xin Guan, Xiaoxia Han, Xiaowan Bo, Shaoyue Li, Liping Sun, Yu Chen, Wenwen Yue, Huixiong Xu.  (2021)  Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation.  ACS Nano,  15  (12): (20414–20429). 
18. Xiao Kuang, Dongxu Chi, Jinbo Li, Chunlin Guo, Yinxian Yang, Shuang Zhou, Cong Luo, Hongzhuo Liu, Zhonggui He, Yongjun Wang.  (2021)  Disulfide bond based cascade reduction-responsive Pt(IV) nanoassemblies for improved anti-tumor efficiency and biosafety.  COLLOIDS AND SURFACES B-BIOINTERFACES,  203  (111766). 
19. Shan Shuhua, Lu Yang, Zhang Xiaoli, Shi Jiangying, Li Hanqing, Li Zhuoyu.  (2021)  Inhibitory effect of bound polyphenol from foxtail millet bran on miR-149 methylation increases the chemosensitivity of human colorectal cancer HCT-8/Fu cells.  MOLECULAR AND CELLULAR BIOCHEMISTRY,  476  (2): (513-523). 
20. Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou.  (2019)  Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.  International Journal of Biological Sciences,  15  (8): ( 1676–1684). 
21. Yang Lu, Shuhua Shan, Hanqing Li, Jiangying Shi, Xiaoli Zhang, Zhuoyu Li.  (2018)  Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  66  (20): (5190–5199). 
22. Tsai Hsiang-I, Jiang Lijuan, Zeng Xiaowei, Chen Hongbo, Li Zihuang, Cheng Wei, Zhang Jinxie, Pan Jie, Wan Dong, Gao Li, Xie Zhenhua, Huang Laiqiang, Mei Lin, Liu Gan.  (2018)  DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy.  Frontiers in Pharmacology,   
23. Gan Liu, Hongjun Gao, Yixiong Zuo, Xiaowei Zeng, Wei Tao, Hsiang-i Tsai, Lin Mei.  (2017)  DACHPt-Loaded Unimolecular Micelles Based on Hydrophilic Dendritic Block Copolymers for Enhanced Therapy of Lung Cancer.  ACS Applied Materials & Interfaces,  (1): (112–119). 
24. Wang Yuying, Su Kunqi, Wang Chang, Deng Tao, Liu Xiaofeng, Sun Shiqi, Jiang Yang, Zhang Chunfeng, Xing Baocai, Du Xiaojuan.  (2024)  Chemotherapy-induced acetylation of ACLY by NAT10 promotes its nuclear accumulation and acetyl-CoA production to drive chemoresistance in hepatocellular carcinoma.  Cell Death & Disease,  15  (7): (1-17). 
25. Mengya Niu, Yihan Pei, Tiantian Jin, Junxiu Li, Liming Bai, Cuixia Zheng, Qingling Song, Hongjuan Zhao, Yun Zhang, Lei Wang.  (2024)  Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer.  Acta Pharmaceutica Sinica B,     
26. Meng-Wei Zhang, Xu Sun, Yi-Wen Xu, Wei Meng, Qiong Tang, Hui Gao, Ling Liu, Shao-Hui Chen.  (2024)  Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response.  CELL BIOLOGY INTERNATIONAL,     
27. Chaofan Nie, Tao Feng, Peiren Wang, Xueqing Jiang, Pandi Peng, Xue Yang, Junru Wang, Luofeng Yu, Yuxin Guo, Peng Li.  (2024)  Dual metabolic modification of tumor-targeted bacteria for synergistic chemo-photodynamic therapy and immunotherapy.  CHEMICAL ENGINEERING JOURNAL,    (154567). 
28. Shiquan Sun, Yong He, Jiaqi Xu, Shaolong Leng, Yu Liu, Huanhuan Wan, Leping Yan, Yunsheng Xu.  (2024)  Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy.  JOURNAL OF CONTROLLED RELEASE,  367  (470). 
29. Hou Xiaodong, Shen Yuting, Huang Bin, Li Qiuyan, Li Shaoyue, Jiang Tingting, Shan Xuexia, Xu Weichen, Liu Shuo, Wu Shengbo, Zhao De, Zhu Anqi, Sun Liping, Xu Huixiong, Yue Wenwen.  (2024)  Losartan-based nanocomposite hydrogel overcomes chemo-immunotherapy resistance by remodeling tumor mechanical microenvironment.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-19). 
30. Siyuan Luo, Yueyan Yang, Liuting Chen, Perumal Ramesh Kannan, Weili Yang, Yongjia Zhang, Ruibo Zhao, Xiaoli Liu, Yao Li, Xiangdong Kong.  (2024)  Outer Membrane Vesicle-Wrapped Manganese Nanoreactor for Augmenting Cancer Metalloimmunotherapy through Hypoxia Attenuation and Immune Stimulation.  Acta Biomaterialia,     
31. Runrun Chi, Luqi Pan, Ziwei Yang, Xiao Yang, Hangbin Xia, Dan Lin, Jiahui Hao, Xiaoqin Si, Dongxue Yan, Huili Li, Changcan Shi, Yuqin Wang, Wenzhong Li.  (2024)  Oxaliplatin-loaded amphiphilic hyaluronic acid nanohydrogel formed via interfacial reactions enhances the therapeutic effect of targeted tumor.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (138118). 
32. Boyao Sun, Xuewei Zheng, Xiaoyu Zhang, Huaiyu Zhang, Yang Jiang.  (2024)  Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy–Ferroptosis Combined Therapy for Gastric Cancer.  ACS Omega,  (14): (16676-16686). 
33. Zhicheng Su, Yanjiao Liu.  (2025)  Responsiveness of glycyrrhetinic acid modified liposome toward secretory phospholipase A2 and its growth inhibitory in Colo205 cells.  JOURNAL OF LIPOSOME RESEARCH,     
34. Gankai Huang, Xinyi Huang, Junlin Huang, Xuye Hou, Youquan Zhang, Fang Lai, Ronghui Lin, Kangquan He, Qunhua Long, Hongbing Ji, Kungang Chai.  (2025)  Single-step purification of para-xylene from xylene isomers through a synergistic combination of two robust aluminum-based metal–organic frameworks.  SEPARATION AND PURIFICATION TECHNOLOGY,  354  (129129). 
35. Yuying Li, Wei Yan, Yu Qin, Liwei Zhang, Sheng Xiao.  (2024)  The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  25  (12): (6468). 

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