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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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O124003-25mg
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25mg |
8
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$21.90
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O124003-100mg
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100mg |
≥10
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$49.90
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O124003-250mg
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250mg |
2
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$83.90
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O124003-500mg
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500mg |
1
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$132.90
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O124003-1g
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1g |
1
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$219.90
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O124003-5g
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5g |
1
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$879.90
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Platinum anticancer agent. Induces DNA cross-linking.
| Synonyms | (trans-1,2-Cyclohexanediamine)oxalatoplatinu | [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum | L-OHP |
|---|---|
| Specifications & Purity | ≥99% |
| Biochemical and Physiological Mechanisms | Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin forms platinum-DNA ad |
| Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy. Application: Oxaliplatin has been used:as a chemotherapeutic agent in colon rectal adenocarcinoma SW480 cells by cell viability assay;for monitoring cell survival in hepatocellular carcinoma HepG2 and HepG2/R cells by MTT assay;to determine the growth inhibitory effect on human breast adenocarcinoma MDA-MB-231 cells.
Chemical properties Chemical formula C8H14N2O4Pt Empirical formula [Pt((R,R)-dach)(ox)] Molecular weight 397.28 Metal Pt Theoretical metal content 49 Physical state powder Color white |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic nitrogen compounds |
| Class | Organonitrogen compounds |
| Subclass | Cyclohexylamines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Cyclohexylamines |
| Alternative Parents | Dicarboxylic acids and derivatives Organic transition metal salts Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Not available |
| Substituents | Cyclohexylamine - Dicarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Organic transition metal salt - Amine - Organic salt - Primary amine - Organooxygen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as cyclohexylamines. These are organic compounds containing a cyclohexylamine moiety, which consist of a cyclohexane ring attached to an amine group. |
| External Descriptors | platinum coordination entity |
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| Pubchem Sid | 488196399 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488196399 |
| INCHI | 1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1 |
| InChIKey | ZROHGHOFXNOHSO-BNTLRKBRSA-L |
| Smiles | C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2] |
| Isomeric SMILES | C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2] |
| WGK Germany | 3 |
| RTECS | TP2275850 |
| Molecular Weight | 397.29 |
| Reaxy-Rn | 14621501 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 28, 2025 | O124003 | |
| Certificate of Analysis | Mar 28, 2025 | O124003 | |
| Certificate of Analysis | Mar 28, 2025 | O124003 | |
| Certificate of Analysis | Mar 28, 2025 | O124003 | |
| Certificate of Analysis | Mar 28, 2025 | O124003 | |
| Certificate of Analysis | Mar 28, 2025 | O124003 | |
| Certificate of Analysis | Aug 19, 2024 | O124003 | |
| Certificate of Analysis | Aug 19, 2024 | O124003 | |
| Certificate of Analysis | Aug 19, 2024 | O124003 | |
| Certificate of Analysis | Aug 19, 2024 | O124003 | |
| Certificate of Analysis | Aug 19, 2024 | O124003 | |
| Certificate of Analysis | Apr 24, 2024 | O124003 | |
| Certificate of Analysis | Apr 24, 2024 | O124003 | |
| Certificate of Analysis | Apr 24, 2024 | O124003 | |
| Certificate of Analysis | Apr 24, 2024 | O124003 | |
| Certificate of Analysis | Apr 24, 2024 | O124003 | |
| Certificate of Analysis | Apr 24, 2024 | O124003 | |
| Certificate of Analysis | Apr 24, 2024 | O124003 | |
| Certificate of Analysis | Jun 19, 2023 | O124003 | |
| Certificate of Analysis | Jun 19, 2023 | O124003 | |
| Certificate of Analysis | Jun 19, 2023 | O124003 | |
| Certificate of Analysis | Jun 19, 2023 | O124003 | |
| Certificate of Analysis | Jun 19, 2023 | O124003 | |
| Certificate of Analysis | Jun 19, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Mar 08, 2023 | O124003 | |
| Certificate of Analysis | Jul 21, 2022 | O124003 | |
| Certificate of Analysis | Jul 21, 2022 | O124003 | |
| Certificate of Analysis | Jul 21, 2022 | O124003 | |
| Certificate of Analysis | Jul 21, 2022 | O124003 | |
| Certificate of Analysis | Jul 21, 2022 | O124003 | |
| Certificate of Analysis | Jul 21, 2022 | O124003 | |
| Certificate of Analysis | Feb 18, 2022 | O124003 | |
| Certificate of Analysis | Feb 18, 2022 | O124003 | |
| Certificate of Analysis | Feb 18, 2022 | O124003 | |
| Certificate of Analysis | Feb 18, 2022 | O124003 | |
| Certificate of Analysis | Feb 18, 2022 | O124003 |
| Solubility | DMSO:DMSO inactivates the activity of Oxaliplatin;H2O:Sonification and heating to 60℃ are recommended;DMF:Sonification is recommended; |
|---|---|
| Sensitivity | Heat Sensitive;Moisture sensitive;Light sensitive |
| Molecular Weight | 397.290 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 0 |
| Exact Mass | 397.06 Da |
| Monoisotopic Mass | 397.06 Da |
| Topological Polar Surface Area | 76.600 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 191.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 3 |
Starting at $49.90
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| 2. Chenyi Gao, Kunpeng Jia, Jun Fang, Xuan Zhu, Jianming Hu, Yi Zhang, Jinxin Jiang, Xiuyan Yu, Danting Wang, Haochen Gu, Zhigang Chen. (2023) CD95 promotes stemness of colorectal cancer cells by lncRNA MALAT1. LIFE SCIENCES, (122394). |
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| 4. Ting Li, Wei Lu, Hui Tian, Yu Cao, Qianqian He, Xia Chen, Hailong Wang. (2023) Identification and Characterization of DNA–Oxaliplatin Adducts through α-hemolysin Nanopores. ANALYTICAL CHEMISTRY, |
| 5. Yudi Ma, Xiaohui Lai, Zhongling Wen, Ziling Zhou, Minkai Yang, Qingqing Chen, Xuan Wang, Feng Mei, Liu Yang, Tongming Yin, Shucun Sun, Guihua Lu, Jinliang Qi, Hongyan Lin, Hongwei Han, Yonghua Yang. (2023) Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment. BIOORGANIC CHEMISTRY, 139 (106703). |
| 6. Yuehong Zhang, Xuelin Huang, Wen-Jun Xin, Shilang He, Jie Deng, Xiangcai Ruan. (2023) Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice. JOURNAL OF PAIN, 24 (1020). |
| 7. Chen Huang, Tao Zhou, Lihua Ma, Shipeng Zhao. (2023) IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46 (1): (26-34). |
| 8. Yuzhu Cao, Yawen Xia, Yufei Wang, Hang Shi, Yuanyuan Wu, Yin Lu. (2023) MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells. Journal of Clinical and Translational Hepatology, 11 (3): ( 584–594). |
| 9. Zhi-Bin Dong, Yu-Jia Wang, Meng-Lin Cheng, Bo-Jun Wang, Hong Lu, Hai-Li Zhu, Ling Liu, Min Xie. (2022) 2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction. PLoS One, 17 (10): (e0275428). |
| 10. He-Yu Yang, Ji Wu, Hong Lu, Meng-Lin Cheng, Bang-Hua Wang, Hai-Li Zhu, Ling Liu, Min Xie. (2022) Emodin suppresses oxaliplatin-induced neuropathic pain by inhibiting COX2/NF-κB mediated spinal inflammation. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 37 (1): (e23229). |
| 11. Zhi-Bin Dong, Yu-Jia Wang, Wen-Jun Wan, Ji Wu, Bo-Jun Wang, Hai-Li Zhu, Min Xie, Ling Liu. (2022) Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Experimental and Therapeutic Medicine, 24 (3): (1-10). |
| 12. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). |
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| 15. Yuzhu Cao, Keqin Lu, Yawen Xia, Yufei Wang, Aiyun Wang, Yang Zhao. (2022) Danshensu Attenuated Epithelial-Mesenchymal Transformation and Chemoresistance of Colon Cancer Cells Induced by Platelets. Frontiers in Bioscience-Landmark, 27 (5): (160). |
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| 17. Yuting Shen, Liang Chen, Xin Guan, Xiaoxia Han, Xiaowan Bo, Shaoyue Li, Liping Sun, Yu Chen, Wenwen Yue, Huixiong Xu. (2021) Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation. ACS Nano, 15 (12): (20414–20429). |
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| 19. Shan Shuhua, Lu Yang, Zhang Xiaoli, Shi Jiangying, Li Hanqing, Li Zhuoyu. (2021) Inhibitory effect of bound polyphenol from foxtail millet bran on miR-149 methylation increases the chemosensitivity of human colorectal cancer HCT-8/Fu cells. MOLECULAR AND CELLULAR BIOCHEMISTRY, 476 (2): (513-523). |
| 20. Peihai Cao, Yiqun Xia, Wei He, Tingting Zhang, Lin Hong, Peisen Zheng, Xin Shen, Guang Liang, Ri Cui, Peng Zou. (2019) Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS. International Journal of Biological Sciences, 15 (8): ( 1676–1684). |
| 21. Yang Lu, Shuhua Shan, Hanqing Li, Jiangying Shi, Xiaoli Zhang, Zhuoyu Li. (2018) Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (20): (5190–5199). |
| 22. Tsai Hsiang-I, Jiang Lijuan, Zeng Xiaowei, Chen Hongbo, Li Zihuang, Cheng Wei, Zhang Jinxie, Pan Jie, Wan Dong, Gao Li, Xie Zhenhua, Huang Laiqiang, Mei Lin, Liu Gan. (2018) DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy. Frontiers in Pharmacology, 9 |
| 23. Gan Liu, Hongjun Gao, Yixiong Zuo, Xiaowei Zeng, Wei Tao, Hsiang-i Tsai, Lin Mei. (2017) DACHPt-Loaded Unimolecular Micelles Based on Hydrophilic Dendritic Block Copolymers for Enhanced Therapy of Lung Cancer. ACS Applied Materials & Interfaces, 9 (1): (112–119). |
| 24. Wang Yuying, Su Kunqi, Wang Chang, Deng Tao, Liu Xiaofeng, Sun Shiqi, Jiang Yang, Zhang Chunfeng, Xing Baocai, Du Xiaojuan. (2024) Chemotherapy-induced acetylation of ACLY by NAT10 promotes its nuclear accumulation and acetyl-CoA production to drive chemoresistance in hepatocellular carcinoma. Cell Death & Disease, 15 (7): (1-17). |
| 25. Mengya Niu, Yihan Pei, Tiantian Jin, Junxiu Li, Liming Bai, Cuixia Zheng, Qingling Song, Hongjuan Zhao, Yun Zhang, Lei Wang. (2024) Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer. Acta Pharmaceutica Sinica B, |
| 26. Meng-Wei Zhang, Xu Sun, Yi-Wen Xu, Wei Meng, Qiong Tang, Hui Gao, Ling Liu, Shao-Hui Chen. (2024) Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response. CELL BIOLOGY INTERNATIONAL, |
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| 35. Yuying Li, Wei Yan, Yu Qin, Liwei Zhang, Sheng Xiao. (2024) The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (12): (6468). |