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OTSSP167 hydrochloride - 99%, high purity , CAS No.1431698-10-0

COA

Grade & Purity:

≥99%

Cas Number: 1431698-10-0
Molecular Weight: 523.88
PubChem CID: 135565272

In stock

Item Number

O648882

Grouped product items
SKU	Size	Availability	Price
O648882-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90
O648882-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
O648882-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
O648882-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90
O648882-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90

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MELK (11) PI3K/Akt/mTOR (765)

Basic Description

Synonyms	MFCD25562907 \| OTSSP167 hydrochloride \| AC-36802 \| HY-15512A \| OTS-167 monohydrochloride \| Ethanone, 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((trans-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)-, hydrochloride (1:1) \| OTSSP167 (hydrochl
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with IC 50 value of 0.41 nM.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with IC 50 value of 0.41 nM. In Vitro OTSSP167 inhibits the growth of A549 (lung), T47D (breast), DU4475 (breast), 22Rv1 (prostate) and HT1197 (bladder) cancer cells with IC 50 values of 6.7, 4.3, 2.3, 6.0 and 97 nM, respectively. OTSSP167 can abrogate the mitotic checkpoint, disrupt MCC and MCC-APC/C interaction in MCF7 cells. OTSSP167 causes GFP-MELK localization to cell cortex in prometaphase cells. OTSSP167 is a MELK selective inhibitor, exhibits a strong in vitro activity, conferring an IC 50 of 0.41 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo OTSSP167 (20 mg/kg, i.v.) results in tumor growth inhibition (TGI) of 73% in xenograft mouse model; OTSSP167 (1, 5, and 10 mg/kg, p.o.) reveals TGI of 51, 91, and 108%, respectively. OTSSP167 (20 mg/kg, p.o.) shows no tumor growth suppressive effect on PC-14 xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.41 nM (MELK)

Names and Identifiers

IUPAC Name	1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone;hydrochloride
INCHI	InChI=1S/C25H28Cl2N4O2.ClH/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3;/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29);1H
InChIKey	XDGWHISAOWEFML-UHFFFAOYSA-N
Smiles	CC(=O)C1=CN=C2C=CC(=NC2=C1NC3CCC(CC3)CN(C)C)C4=CC(=C(C(=C4)Cl)O)Cl.Cl
Isomeric SMILES	CC(=O)C1=CN=C2C=CC(=NC2=C1NC3CCC(CC3)CN(C)C)C4=CC(=C(C(=C4)Cl)O)Cl.Cl
Alternate CAS	1431698-10-0
PubChem CID	135565272
Molecular Weight	523.88

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 33.33 mg/mL (63.62 mM; Need ultrasonic) H2O : 7.14 mg/mL (13.63 mM; Need ultrasonic)
Molecular Weight	523.900 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	522.136 Da
Monoisotopic Mass	522.136 Da
Topological Polar Surface Area	78.400 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	648.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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