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OSMI-1 - ≥98%, high purity , CAS No.1681056-61-0

COA

Grade & Purity:

≥98%

Cas Number: 1681056-61-0
Molecular Weight: 563.64
PubChem CID: 118634407
PubChem SID: 504772878

In stock

Item Number

O276038

Grouped product items
SKU	Size	Availability	Price
O276038-5mg	5mg	3	$97.90
O276038-10mg	10mg	2	$162.90
O276038-25mg	25mg	1	$271.90
O276038-50mg	50mg	1	$489.90
O276038-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$882.90
O276038-200mg	200mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,587.90

Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor.

View related series

Acyltransferase (66) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	E78764 \| HY-119738 \| 1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2- \| (R)-N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide \| OSMI-1, >=98% (HPLC) \| DTXSID401104617 \| (alphaR)-alpha-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor. Inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.OGT catalyses the attachment of N-acetylglucosamine moieties
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycan. Application： OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acid amides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Alpha amino acid amides
Alternative Parents	Hydroquinolones Phenylacetamides Hydroquinolines Phenoxy compounds Methoxybenzenes Anisoles Pyridinones Alkyl aryl ethers Organosulfonamides Thiophenes Tertiary carboxylic acid amides Heteroaromatic compounds Furans Aminosulfonyl compounds Lactams Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Alpha-amino acid amide - Dihydroquinolone - Phenylacetamide - Quinoline - Dihydroquinoline - Phenoxy compound - Methoxybenzene - Phenol ether - Anisole - Pyridinone - Alkyl aryl ether - Benzenoid - Organosulfonic acid amide - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Aminosulfonyl compound - Thiophene - Tertiary carboxylic acid amide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Furan - Lactam - Carboxamide group - Oxacycle - Azacycle - Organoheterocyclic compound - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	504772878
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772878
IUPAC Name	(2R)-N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-[(2-oxo-1H-quinolin-6-yl)sulfonylamino]-N-(thiophen-2-ylmethyl)acetamide
INCHI	InChI=1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1
InChIKey	IYIGLWQQAMROOF-HHHXNRCGSA-N
Smiles	COC1=CC=CC=C1C(C(=O)N(CC2=CC=CO2)CC3=CC=CS3)NS(=O)(=O)C4=CC5=C(C=C4)NC(=O)C=C5
Isomeric SMILES	COC1=CC=CC=C1[C@H](C(=O)N(CC2=CC=CO2)CC3=CC=CS3)NS(=O)(=O)C4=CC5=C(C=C4)NC(=O)C=C5
Molecular Weight	563.64
Reaxy-Rn	56504464
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=56504464&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
E2513054	Certificate of Analysis	May 20, 2025	O276038
H2427063	Certificate of Analysis	Sep 06, 2024	O276038
G2311585	Certificate of Analysis	Apr 12, 2024	O276038
G2311444	Certificate of Analysis	Apr 12, 2024	O276038
G2311442	Certificate of Analysis	Apr 12, 2024	O276038
G2311436	Certificate of Analysis	Apr 12, 2024	O276038
G2311433	Certificate of Analysis	Apr 07, 2024	O276038
G2311440	Certificate of Analysis	Apr 07, 2024	O276038
G2311432	Certificate of Analysis	Apr 07, 2024	O276038
G2311438	Certificate of Analysis	Apr 07, 2024	O276038
G2311441	Certificate of Analysis	Apr 07, 2024	O276038
G2311430	Certificate of Analysis	Apr 07, 2024	O276038

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Chemical and Physical Properties

Solubility	DMSO: 20 mg/mL
Sensitivity	Light sensitive
Molecular Weight	563.600 g/mol
XLogP3	3.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	563.118 Da
Monoisotopic Mass	563.118 Da
Topological Polar Surface Area	155.000 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	1000.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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