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OSI-420 - 98%, high purity , CAS No.183320-51-6

COA

Grade & Purity:

≥98%

Cas Number: 183320-51-6
Molecular Weight: 415.87
PubChem CID: 18924996
PubChem SID: 488199672

In stock

Item Number

O125033

Grouped product items
SKU	Size	Availability	Price
O125033-1mg	1mg	3	$66.90
O125033-5mg	5mg	3	$141.90
O125033-10mg	10mg	5	$248.90
O125033-25mg	25mg	5	$560.90
O125033-50mg	50mg	5	$634.90

View related series

Drug Metabolite (241) Metabolic Enzyme/Protease (4860) Metabolite (5307)

Basic Description

Synonyms	OSI420 HCl \| DTXSID50596524 \| BCP28007 \| OSI-420;CP-473420 \| FT-0778034 \| OSI 420 \| LY2784544;Gandotinib \| 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol hydrochloride \| DesMethyl Erlotinib (CP-473420) HCl \| Desmethyl Erloti
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazanaphthalenes
    - Subclass Benzodiazines
      - Level5 Quinazolines
        Level6 Quinazolinamines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazanaphthalenes
Subclass	Benzodiazines
Intermediate Tree Nodes	Quinazolines
Direct Parent	Quinazolinamines
Alternative Parents	Phenol ethers Aniline and substituted anilines Aminopyrimidines and derivatives Alkyl aryl ethers Imidolactams Heteroaromatic compounds Dialkyl ethers Azacyclic compounds Acetylides Primary alcohols Hydrochlorides Hydrocarbon derivatives Amines
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinazolinamine - Phenol ether - Aniline or substituted anilines - Alkyl aryl ether - Aminopyrimidine - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Benzenoid - Heteroaromatic compound - Acetylide - Dialkyl ether - Ether - Azacycle - Organooxygen compound - Organonitrogen compound - Amine - Organic nitrogen compound - Alcohol - Hydrocarbon derivative - Primary alcohol - Organic oxygen compound - Hydrochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	488199672
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488199672
IUPAC Name	2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol;hydrochloride
INCHI	InChI=1S/C21H21N3O4.ClH/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21;/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24);1H
InChIKey	BUOXOWNQZVIETJ-UHFFFAOYSA-N
Smiles	COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl
Isomeric SMILES	COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl
Alternate CAS	183321-86-0
Molecular Weight	415.87
Reaxy-Rn	13434158
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13434158&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
F2516060	Certificate of Analysis	Jul 04, 2025	O125033
C2329417	Certificate of Analysis	Jan 13, 2025	O125033
C2329450	Certificate of Analysis	Jan 13, 2025	O125033
C2328673	Certificate of Analysis	Jan 13, 2025	O125033
C23281112	Certificate of Analysis	Jan 13, 2025	O125033
C23281116	Certificate of Analysis	Jan 13, 2025	O125033
C23281108	Certificate of Analysis	Jan 13, 2025	O125033
C23281129	Certificate of Analysis	Jan 13, 2025	O125033
C2329602	Certificate of Analysis	Jan 13, 2025	O125033
C23281111	Certificate of Analysis	Jan 08, 2025	O125033
C2328679	Certificate of Analysis	Jan 08, 2025	O125033

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Chemical and Physical Properties

Solubility	DMSO 83 mg/mL Water 2 mg/mL Ethanol <1 mg/mL
Sensitivity	Moisture sensitive.
Molecular Weight	415.900 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Exact Mass	415.13 Da
Monoisotopic Mass	415.13 Da
Topological Polar Surface Area	85.700 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	511.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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