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OB 24 hydrochloride - ≥98%(HPLC), high purity , CAS No.939825-12-4

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OB 24 hydrochloride - ≥98%(HPLC), high purity , CAS No.939825-12-4

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 939825-12-4
Molecular Weight: 373.67
PubChem CID: 45265865

In stock

Item Number

O287680

Grouped product items
SKU	Size	Availability	Price
O287680-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$107.90
O287680-5mg	5mg	3	$374.90
O287680-10mg	10mg	3	$599.90
O287680-25mg	25mg	3	$1,099.90
O287680-50mg	50mg	2	$1,699.90

Potent and selective heme oxygenase 1 (HO-1) inhibitor

Basic Description

Synonyms	SCHEMBL407935 \| UNII-B2FQJ9RF5L \| 1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride \| 1H-Imidazole, 1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-, hydrochloride (1:1) \| 2-(2-(4-Bromophenyl)ethyl)-2-((1H-imidaz
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferatio
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	OB-24 is a potent inhibitor of heme oxygenase-1 (HO-1). Heme oxygenase-1, a member of the heat shock protein family, plays a key role as a sensor and regulator of oxidative stress. OB-24 significantly inhibited cell proliferation in vitro and tumor growth and lymph node/lung metastases in vivo. OB-24 has potential for the research of advanced prostate cancer (PCA).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Phenylbutylamines

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Phenylbutylamines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylbutylamines
Alternative Parents	Ketals Bromobenzenes N-substituted imidazoles Aryl bromides Heteroaromatic compounds 1,3-dioxolanes Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organobromides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Phenylbutylamine - Ketal - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - N-substituted imidazole - Meta-dioxolane - Azole - Heteroaromatic compound - Imidazole - Acetal - Oxacycle - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Hydrochloride - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylbutylamines. These are compounds containing a phenylbutylamine moiety, which consists of a phenyl group substituted at the fourth carbon by an butan-1-amine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HMOX2 Tchem Heme oxygenase 2 (250 Activities)

Discover Target: HMOX2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HMOX1 Tchem Heme oxygenase 1 (32 Activities)

Discover Target: HMOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-[[2-[2-(4-bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]imidazole;hydrochloride
INCHI	InChI=1S/C15H17BrN2O2.ClH/c16-14-3-1-13(2-4-14)5-6-15(19-9-10-20-15)11-18-8-7-17-12-18;/h1-4,7-8,12H,5-6,9-11H2;1H
InChIKey	YSOWYXRHOAXXTG-UHFFFAOYSA-N
Smiles	C1COC(O1)(CCC2=CC=C(C=C2)Br)CN3C=CN=C3.Cl
Isomeric SMILES	C1COC(O1)(CCC2=CC=C(C=C2)Br)CN3C=CN=C3.Cl
Molecular Weight	373.67
Reaxy-Rn	11085683
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11085683&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
D2419512	Certificate of Analysis	Feb 01, 2024	O287680
D2419513	Certificate of Analysis	Feb 01, 2024	O287680
D2419514	Certificate of Analysis	Feb 01, 2024	O287680
D2419515	Certificate of Analysis	Feb 01, 2024	O287680
D2419516	Certificate of Analysis	Feb 01, 2024	O287680
D2419517	Certificate of Analysis	Feb 01, 2024	O287680
D2419548	Certificate of Analysis	Feb 01, 2024	O287680
D2419549	Certificate of Analysis	Feb 01, 2024	O287680

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 37.37, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 37.37, Max Conc. mM: 100
Molecular Weight	373.670 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	372.024 Da
Monoisotopic Mass	372.024 Da
Topological Polar Surface Area	36.300 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	302.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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