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O8 OGG1 Inhibitor - ≥98%(HPLC), high purity , CAS No.350997-39-6

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O8 OGG1 Inhibitor - ≥98%(HPLC), high purity , CAS No.350997-39-6

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 350997-39-6
Molecular Weight: 261.13
PubChem CID: 874733
PubChem SID: 488191657

In stock

Item Number

O287618

Grouped product items
SKU	Size	Availability	Price
O287618-5mg	5mg	3	$60.90
O287618-10mg	10mg	2	$109.90
O287618-25mg	25mg	1	$261.90
O287618-50mg	50mg	1	$470.90
O287618-100mg	100mg	1	$846.90
O287618-250mg	250mg	1	$1,904.90

Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

View related series

Cell Cycle (2830)

Basic Description

Synonyms	AB00102917-01 \| AKOS003956278 \| BBL037375 \| Cambridge id 6132595 \| 3,4-dichlorobenzo[b]thiophene-2-carbohydrazide \| HY-112902 \| MFCD01993639 \| OGG1-IN-O8 \| 3,4-dichloro-1-benzothiophene-2-carbohydrazide \| O8 OGG1 Inhibitor- Bio-X \| OGG1-IN-08 \| OGG1 inhib
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50= 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzothiophenes
    - Subclass 1-benzothiophenes

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzothiophenes
Subclass	1-benzothiophenes
Intermediate Tree Nodes	Not available
Direct Parent	1-benzothiophenes
Alternative Parents	Thiophene carboxamides Benzenoids Aryl chlorides Vinylogous halides Heteroaromatic compounds Carboxylic acid hydrazides Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	1-benzothiophene - Thiophene carboxamide - Thiophene carboxylic acid or derivatives - Aryl chloride - Aryl halide - Benzenoid - Heteroaromatic compound - Vinylogous halide - Thiophene - Carboxylic acid hydrazide - Carboxylic acid derivative - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 1-benzothiophenes. These are aromatic heterocyclic compound containing the Benzo[b]thiophene ring system.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

OGG1 Tchem N-glycosylase/DNA lyase (6 Activities)

Discover Target: OGG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OGG1 Tchem N-glycosylase/DNA lyase (81 Activities)

Discover Target: OGG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NTHL1 Tbio Endonuclease III-like protein 1 (51 Activities)

Discover Target: NTHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

mutM Formamidopyrimidine-DNA glycosylase (36 Activities)

Discover Target: mutM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488191657
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488191657
IUPAC Name	3,4-dichloro-1-benzothiophene-2-carbohydrazide
INCHI	InChI=1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)
InChIKey	HSSHUDKWJRJKPV-UHFFFAOYSA-N
Smiles	C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl
Isomeric SMILES	C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl
Molecular Weight	261.13
Reaxy-Rn	28962077
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28962077&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
C2329382	Certificate of Analysis	Jan 06, 2023	O287618
C23281117	Certificate of Analysis	Jan 06, 2023	O287618
C23281118	Certificate of Analysis	Jan 06, 2023	O287618
C23281120	Certificate of Analysis	Jan 06, 2023	O287618
C23281119	Certificate of Analysis	Jan 06, 2023	O287618
C2329410	Certificate of Analysis	Jan 06, 2023	O287618
C2329597	Certificate of Analysis	Jan 06, 2023	O287618
C23281122	Certificate of Analysis	Jan 06, 2023	O287618
C23281123	Certificate of Analysis	Jan 06, 2023	O287618
C23281124	Certificate of Analysis	Jan 06, 2023	O287618
C23281125	Certificate of Analysis	Jan 06, 2023	O287618
C2329381	Certificate of Analysis	Jan 06, 2023	O287618

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 26.11, Max Conc. mM: 100
Molecular Weight	261.130 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	259.958 Da
Monoisotopic Mass	259.958 Da
Topological Polar Surface Area	83.400 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	266.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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