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O-Phospho-L-tyrosine - ≥95.0%(HPLC), high purity , CAS No.21820-51-9

3 Citations

COA

Grade & Purity:

≥95%(HPLC)

Cas Number: 21820-51-9
Molecular Weight: 261.17
MDL number: MFCD00002603
PubChem CID: 30819
PubChem SID: 504753417

In stock

Item Number

O132562

Grouped product items
SKU	Size	Availability	Price
O132562-10mg	10mg	10	$9.90
O132562-50mg	50mg	8	$27.90
O132562-250mg	250mg	6	$106.90
O132562-1g	1g	3	$317.90
O132562-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,427.90

Tyrosine-phosphorylation reagent.

View related series

Element classified compounds (2014) Phosphorus compounds (460)

Basic Description

Synonyms	(S)-2-amino-3-(4-(phosphonooxy)phenyl)propanoic acid \| H-Tyr(PO)-OH \| AS-19190 \| CHEBI:37788 \| O(4)-phosphono-L-tyrosine \| DTXSID00176234 \| H-Tyr(PO3H2)-OH \| Tyrosine, phosphate (6CI) \| AKOS015894042 \| J-014304 \| P0959 \| L-Tyrosine, dihydrogen phosphate (
Specifications & Purity	≥95%(HPLC)
Biochemical and Physiological Mechanisms	Useful reagent in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Phenylalanine and derivatives

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Phenylalanine and derivatives
Alternative Parents	Phenylpropanoic acids Phenyl phosphates L-alpha-amino acids Amphetamines and derivatives Phenoxy compounds Aralkylamines Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Phenylalanine or derivatives - 3-phenylpropanoic-acid - Phenyl phosphate - Alpha-amino acid - L-alpha-amino acid - Amphetamine or derivatives - Aryl phosphomonoester - Aryl phosphate - Phenoxy compound - Aralkylamine - Phosphoric acid ester - Monocyclic benzene moiety - Organic phosphoric acid derivative - Benzenoid - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Primary amine - Hydrocarbon derivative - Primary aliphatic amine - Organic oxide - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors	non-proteinogenic L-alpha-amino acid - L-tyrosine derivative - O(4)-phosphotyrosine
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

Discover Target: LCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

Discover Target: SRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)

Discover Target: PTPN11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Grb2 Growth factor receptor-bound protein 2 (49 Activities)

Discover Target: Grb2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504753417
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753417
IUPAC Name	(2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid
INCHI	InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1
InChIKey	DCWXELXMIBXGTH-QMMMGPOBSA-N
Smiles	C1=CC(=CC=C1CC(C(=O)O)N)OP(=O)(O)O
Isomeric SMILES	C1=CC(=CC=C1C[C@@H](C(=O)O)N)OP(=O)(O)O
Molecular Weight	261.17
Reaxy-Rn	4260804
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4260804&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot Number	Certificate Type	Date	Item
A2314189	Certificate of Analysis	Oct 16, 2024	O132562
A2314245	Certificate of Analysis	Oct 15, 2024	O132562
A2314219	Certificate of Analysis	Oct 15, 2024	O132562
A2314190	Certificate of Analysis	Oct 15, 2024	O132562
J2127395	Certificate of Analysis	Aug 04, 2023	O132562
J2127499	Certificate of Analysis	Aug 04, 2023	O132562
J2127364	Certificate of Analysis	Aug 04, 2023	O132562
J2127384	Certificate of Analysis	Aug 04, 2023	O132562
I1930109	Certificate of Analysis	Jun 06, 2023	O132562
A2314197	Certificate of Analysis	Nov 18, 2022	O132562
C2425072	Certificate of Analysis	Nov 18, 2022	O132562
C2426024	Certificate of Analysis	Nov 18, 2022	O132562
C2427040	Certificate of Analysis	Nov 18, 2022	O132562

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Chemical and Physical Properties

Sensitivity	heat sensitive
Specific Rotation[α]	-6° (C=1,2mol/L HCl)
Molecular Weight	261.170 g/mol
XLogP3	-2.800
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	261.04 Da
Monoisotopic Mass	261.04 Da
Topological Polar Surface Area	130.000 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	309.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yuyan Guo, Tao Gao, Fang Fang, Shuang Sun, Dayu Yang, Yongji Li, Shaowa Lv. (2021) A novel polymer micelle as a targeted drug delivery system for 10-hydroxycamptothecin with high drug-loading properties and anti-tumor efficacy. BIOPHYSICAL CHEMISTRY, 279 (106679).
2. Fen-Ying Kong, Hui-Yu Zou, Meng Xiong, Jia-Dong Zhang, Wei Wang, Wei-Wei Zhao. (2021) 3D NiO nanoflakes/carbon fiber meshwork: Facile preparation and utilization as general platform for photocathodic bioanalysis. ANALYTICA CHIMICA ACTA, 1143 (173).
3. Xia Cheng, Yuying Chai, Jian Xu, Lin Wang, Fangdi Wei, Guanhong Xu, Yong Sun, Qin Hu, Yao Cen. (2020) Enzyme cascade reaction-based ratiometric fluorescence probe for visual monitoring the activity of alkaline phosphatase. SENSORS AND ACTUATORS B-CHEMICAL, 309 (127765).

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