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Ω-conotoxin GVIA, Channel blocker of Ca v2.1;Channel blocker of Ca v2.2, CAS No.92078-76-7, Channel blocker of Ca v2.1;Channel blocker of Ca v2.2

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Item Number
rp174689
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Price Qty
rp174689-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
rp174689-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,334.90

Basic Description

Product Name Ω-conotoxin GVIA, Channel blocker of Ca v2.1;Channel blocker of Ca v2.2, CAS No.92078-76-7
Synonyms omega-Conopeptide gvia | toxin, omega-Conus geographus | Conus geographus toxin | Snx 124 | DTXSID60238847 | CA669FO97Q | GTPL2535 | UNII-CA669FO97Q | omega-Cgtx gvia | omega Cgtx | omega-Ctx | omega-Cgtx | omega-Conotoxin G VIA (reduced) | omega Conus ge
Grade Moligand™
Specifications & Purity Moligand™
Action Type CHANNEL BLOCKER
Mechanism of action Channel blocker of Ca v2.1;Channel blocker of Ca v2.2

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Not available
Direct Parent Peptides
Alternative Parents N-acyl-alpha amino acids and derivatives  Alpha amino acid amides  Amphetamines and derivatives  N-acylpyrrolidines  1-hydroxy-2-unsubstituted benzenoids  Tertiary carboxylic acid amides  Secondary alcohols  Guanidines  Propargyl-type 1,3-dipolar organic compounds  Alkylthiols  Azacyclic compounds  Carboximidamides  Carboximidic acids  Carbonyl compounds  Organic oxides  Primary alcohols  Monoalkylamines  Hydrocarbon derivatives  Imines  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Alpha peptide - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Amphetamine or derivatives - N-acylpyrrolidine - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Benzenoid - Pyrrolidine - Tertiary carboxylic acid amide - Secondary alcohol - Guanidine - Carboxamide group - Amino acid or derivatives - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Azacycle - Carboximidic acid - Carboximidic acid derivative - Alkylthiol - Carboximidamide - Alcohol - Imine - Primary aliphatic amine - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Carbonyl group - Primary alcohol - Primary amine - Hydrocarbon derivative - Amine - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
External Descriptors Not available

Associated Targets(Human)

CACNA1A Tchem Voltage-dependent P/Q-type calcium channel subunit alpha-1A (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CACNA1B Tclin Voltage-dependent N-type calcium channel subunit alpha-1B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

CAS 92078-76-7

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names omega-Conopeptide gvia | toxin, omega-Conus geographus | Conus geographus toxin | Snx 124 | DTXSID60238847 | CA669FO97Q | GTPL2535 | UNII-CA669FO97Q | omega-Cgtx gvia | omega Cgtx | omega-Ctx | omega-Cgtx | omega-Conotoxin G VIA (reduced) | omega Conus ge
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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