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NSC12 - 98%, high purity , CAS No.102586-30-1

COA

Grade & Purity:

≥98%

Cas Number: 102586-30-1
Molecular Weight: 484.52
PubChem CID: 24843124
PubChem SID: 488200702

In stock

Item Number

N413880

Grouped product items
SKU	Size	Availability	Price
N413880-1mg	1mg	3	$30.90
N413880-5mg	5mg	3	$127.90
N413880-10mg	10mg	2	$216.90
N413880-25mg	25mg	1	$488.90
N413880-50mg	50mg	1	$878.90
N413880-100mg	100mg	1	$1,581.90

FGFR Inhibitors

View related series

FGFR (112) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	OHKBOEWLASAFLW-DRPHTYIMSA-N \| Pregn-5-ene-3,20-diol, 21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)- \| 21-(Hydroxy(bistrifluoromethyl)methyl)pregnane-3,20-diol \| 4,4,4-trifluoro-1-[(8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,1
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	NSC12 (NSC 172285) is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information NSC12 NSC12 (NSC 172285) is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. Targets FGF3 (Cell-free assay); FGF8b (Cell-free assay); FGF22 (Cell-free assay); FGF20 (Cell-free assay); FGF2/FGFR (Cell-free assay) 16447,15.9 μM(Kd); 18.9 μM(Kd) ;26.8 μM(Kd); 29.4 μM(Kd); 30 μM In vitro NSC12 inhibits FGF-dependent tumor growth, angiogenesis, and metastases. NSC12 does not affect FGF2/heparin interaction, whereas it inhibits the binding of FGF2 to the immobilized receptor (ID50 ∼30 μM). NSC12 interferes with FGF2/FGFR1 interaction without affecting the ability of the growth factor to interact with heparin or HSPGs. NSC12 also binds immobilized FGF3, FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd values ranging between ∼16 and ∼120 μM. NSC12 may act as a multi-FGF trap by interacting with all members of the canonical FGF subfamilies. NSC12 hampers FGF23-mediated FGFR1 activation in Klotho-expressing Chinese hamster ovary (CHO) cells. Treatment with NSC12 causes the reduction of the S phase of the cell cycle in all tumor cell lines but LLC cells, in which an accumulation in the S phase is observed. NSC12 inhibits FGFR1, FGFR2, FGFR3, and FGFR4 phosphorylation in CHO cell transfectants. NSC12 inhibits the proliferation of various FGF-dependent murine and human cancer cell lines with no inhibitory effect on HCC827 cancer cells that harbor a tumor-driving mutation of the EGFR TK domain and on FGF-independent cancer cell lines. In vivo Parenteral and oral delivery of NSC12 inhibits FGFR activation, tumor growth, angiogenesis, and metastasis in FGF-dependent murine and human tumor models. NSC12 causes a significant decrease of tumor weight, tumor cell FGFR1 phosphorylation and proliferation, and tumor CD31+ neovascularization at all the doses tested in the animal models. Cell Research(from reference) Cell lines：KATO Ⅲ cells Concentrations：1.0 or 3.0 μM Incubation Time：72 h

Product Properties

ALogP	4.884
HBD Count	2
Rotatable Bond	5

Names and Identifiers

Pubchem Sid	488200702
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200702
IUPAC Name	4,4,4-trifluoro-1-[(8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-(trifluoromethyl)butane-1,3-diol
INCHI	InChI=1S/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14?,15-,16-,17-,18+,19?,20-,21-/m0/s1
InChIKey	OHKBOEWLASAFLW-DRPHTYIMSA-N
Smiles	CC12CCC3C(C1CCC2C(CC(C(F)(F)F)(C(F)(F)F)O)O)CC=C4C3(CCC(C4)O)C
Isomeric SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(CC(C(F)(F)F)(C(F)(F)F)O)O)CC=C4[C@@]3(CCC(C4)O)C
Molecular Weight	484.52
Reaxy-Rn	29542218
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29542218&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
C2320051	Certificate of Analysis	Dec 21, 2022	N413880
C2320043	Certificate of Analysis	Dec 21, 2022	N413880
C2320044	Certificate of Analysis	Dec 21, 2022	N413880
C2320049	Certificate of Analysis	Dec 21, 2022	N413880
C2320036	Certificate of Analysis	Dec 21, 2022	N413880
C2320059	Certificate of Analysis	Dec 21, 2022	N413880
C2320038	Certificate of Analysis	Dec 21, 2022	N413880
C2320045	Certificate of Analysis	Dec 21, 2022	N413880
C2320056	Certificate of Analysis	Dec 21, 2022	N413880
C2320047	Certificate of Analysis	Dec 21, 2022	N413880

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro Ethanol: 63 mg/mL (130.02 mM); DMSO: 10.3 mg/mL (21.25 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	96
DMSO(mM) Max Solubility	198.1342359
Water(mg / mL) Max Solubility	＜1

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