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NSC 663284 (DA3003-1) - ≥98%, high purity , CAS No.383907-43-5

COA

Grade & Purity:

≥98%

Cas Number: 383907-43-5
Molecular Weight: 321.76
PubChem CID: 379077
PubChem SID: 504758609

In stock

Item Number

N275722

Grouped product items
SKU	Size	Availability	Price
N275722-1mg	1mg	3	$28.90
N275722-5mg	5mg	3	$116.90
N275722-10mg	10mg	2	$207.90
N275722-25mg	25mg	2	$430.90
N275722-50mg	50mg	2	$770.90

Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor

View related series

Epigenetics (1496) Glucose Metabolism (1943) Histone Methyltransferase (190) Histone Modification (1379) Metabolic Enzyme/Protease (4860) Phosphatase (222)

Basic Description

Synonyms	NCGC00092289-02 \| 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione \| NCI60_021732 \| 5,6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]- \| NSC663284 \| NSC-663284 \| A13524 \| CHEBI:92053 \| DTXSID50327512 \| MS-24764 \| CY8W2F69MW \| HMS3412L16 \| DA-3003-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor. Induces cell cycle arrest at both G1 and G2/M phase. Shows antiproliferative effects against tumor cell lines (IC 50 = 0.2-35 μM). Shows antitumor effects in vivo.
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. product description： NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM) application： NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Quinoline quinones

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Quinoline quinones
Intermediate Tree Nodes	Not available
Direct Parent	Quinoline quinones
Alternative Parents	Hydroquinolines Aryl ketones Morpholines Pyridines and derivatives Vinylogous halides Alpha-chloroketones Vinylogous amides Heteroaromatic compounds Trialkylamines Oxacyclic compounds Enamines Dialkylamines Dialkyl ethers Chloroalkenes Azacyclic compounds Vinyl chlorides Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinoline quinone - Dihydroquinoline - Aryl ketone - Morpholine - Oxazinane - Pyridine - Alpha-haloketone - Alpha-chloroketone - Heteroaromatic compound - Vinylogous amide - Vinylogous halide - Ketone - Tertiary amine - Tertiary aliphatic amine - Dialkyl ether - Secondary aliphatic amine - Enamine - Ether - Oxacycle - Secondary amine - Azacycle - Chloroalkene - Vinyl chloride - Vinyl halide - Haloalkene - Organonitrogen compound - Organooxygen compound - Organic oxide - Hydrocarbon derivative - Amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organohalogen compound - Organochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinoline quinones. These are quinoline derivative with a structure containing a 5,8-dihydroisoquinoline-5,8-dione skeleton.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KMT5A Tchem N-lysine methyltransferase KMT5A (2 Activities)

Discover Target: KMT5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDC25A Tchem M-phase inducer phosphatase 1 (2 Activities)

Discover Target: CDC25A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDC25B Tchem M-phase inducer phosphatase 2 (3 Activities)

Discover Target: CDC25B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDC25C Tchem M-phase inducer phosphatase 3 (3 Activities)

Discover Target: CDC25C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504758609
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758609
IUPAC Name	6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione
INCHI	InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChIKey	BMKPVDQDJQWBPD-UHFFFAOYSA-N
Smiles	C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
Isomeric SMILES	C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
Molecular Weight	321.76
Reaxy-Rn	9003440
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9003440&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2525430	Certificate of Analysis	Apr 16, 2025	N275722
I2227740	Certificate of Analysis	Jul 19, 2023	N275722
I2227556	Certificate of Analysis	Jul 13, 2023	N275722
I2227544	Certificate of Analysis	Jul 13, 2023	N275722
I2227505	Certificate of Analysis	Jul 13, 2023	N275722
I2227504	Certificate of Analysis	Jul 13, 2023	N275722

Chemical and Physical Properties

Solubility	Soluble in ethanol to 50 mM and in DMSO to 50 mM
Sensitivity	Light sensitive
Molecular Weight	321.760 g/mol
XLogP3	1.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	321.088 Da
Monoisotopic Mass	321.088 Da
Topological Polar Surface Area	71.500 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	488.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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