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NQTrp - 95%, high purity , CAS No.185351-19-3

COA

Grade & Purity:

≥95%

Cas Number: 185351-19-3
Molecular Weight: 360.36
PubChem CID: 56605052
PubChem SID: 504771422

In stock

Item Number

N286859

Grouped product items
SKU	Size	Availability	Price
N286859-5mg	5mg	2	$98.90
N286859-10mg	10mg	2	$157.90
N286859-25mg	25mg	2	$345.90
N286859-50mg	50mg	2	$543.90
N286859-100mg	100mg	2	$840.90

Potent inhibitor of Aβ oligomer and fibril formation

View related series

Neuronal Signaling (3320) Tau Protein (15)

Basic Description

Synonyms	NQTrp, >=98% (HPLC) \| DTXSID30717912 \| (1,4-dioxo-1,4-dihydronaphthalen-2-yl)-L-tryptophan \| 1,4-naphthoquinon-2-yl-l-tryptophan \| AKOS027470177 \| nqtrp \| HY-19738 \| (2S)-2-[(1,4-DIOXONAPHTHALEN-2-YL)AMINO]-3-(1H-INDOL-3-YL)PROPANOIC ACID \| MS-25694 \| CS-
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Potent inhibitor of Aβoligomer and fibril formation (IC50= 50 nM for formation of fibrils from Aβ1-42). Reduces cytotoxicity of Aβoligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ1-4
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Indolyl carboxylic acids and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Indolyl carboxylic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Indolyl carboxylic acids and derivatives
Alternative Parents	Naphthoquinones 3-alkylindoles L-alpha-amino acids Quinones Aryl ketones Aralkylamines Substituted pyrroles Vinylogous amides Heteroaromatic compounds Monocarboxylic acids and derivatives Enamines Dialkylamines Carboxylic acids Azacyclic compounds Hydrocarbon derivatives Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Indolyl carboxylic acid derivative - Naphthoquinone - Alpha-amino acid - Alpha-amino acid or derivatives - L-alpha-amino acid - Naphthalene - 3-alkylindole - Indole - Quinone - Aryl ketone - Aralkylamine - Substituted pyrrole - Benzenoid - Vinylogous amide - Pyrrole - Heteroaromatic compound - Ketone - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Enamine - Azacycle - Monocarboxylic acid or derivatives - Amine - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Carbonyl group - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. These are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BCHE Tclin Butyrylcholinesterase (7174 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

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Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

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Enterobacter cloacae (7976 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Proteus vulgaris (5823 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Enterococcus faecalis (29875 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504771422
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771422
IUPAC Name	(2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid
INCHI	InChI=1S/C21H16N2O4/c24-19-10-17(20(25)15-7-2-1-6-14(15)19)23-18(21(26)27)9-12-11-22-16-8-4-3-5-13(12)16/h1-8,10-11,18,22-23H,9H2,(H,26,27)/t18-/m0/s1
InChIKey	DZZUYZXINNHEGM-SFHVURJKSA-N
Smiles	C1=CC=C2C(=C1)C(=O)C=C(C2=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O
Isomeric SMILES	C1=CC=C2C(=C1)C(=O)C=C(C2=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O
Molecular Weight	360.36
Reaxy-Rn	25282926
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25282926&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
K2413039	Certificate of Analysis	Jun 15, 2022	N286859
J2214595	Certificate of Analysis	Jun 15, 2022	N286859
J2214597	Certificate of Analysis	Jun 15, 2022	N286859
J2214596	Certificate of Analysis	Jun 15, 2022	N286859
J2214600	Certificate of Analysis	Jun 15, 2022	N286859
J2214598	Certificate of Analysis	Jun 15, 2022	N286859

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 36.04, Max Conc. mM: 100
Molecular Weight	360.400 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	360.111 Da
Monoisotopic Mass	360.111 Da
Topological Polar Surface Area	99.300 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	659.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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NQTrp - 95%, high purity , CAS No.185351-19-3

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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