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NQ 301 - ≥98%(HPLC), high purity , CAS No.130089-98-4

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
N288140
Grouped product items
SKU Size
Availability
 Price Qty
N288140-5mg
5mg
2
$64.90
N288140-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$97.90
N288140-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$162.90
N288140-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$271.90
N288140-100mg
100mg
2
$489.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Selective CD45 inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Metabolic Enzyme/Protease (4860) Thrombin (39)

Basic Description

Synonyms 2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone | 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione | Compound 211
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Selective CD45 inhibitor (IC50= 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytesin vitro. Bloc
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic oxygen compounds
Class Organooxygen compounds
Subclass Carbonyl compounds
Intermediate Tree Nodes Ketones - Aryl ketones - Phenylketones
Direct Parent Alkyl-phenylketones
Alternative Parents Naphthoquinones  Acetophenones  Aniline and substituted anilines  Aryl alkyl ketones  Benzoyl derivatives  Quinones  Secondary alkylarylamines  Vinylogous amides  Vinylogous halides  Alpha-chloroketones  Enamines  Chloroalkenes  Vinyl chlorides  Organochlorides  Organic oxides  Hydrocarbon derivatives  Organopnictogen compounds  
Molecular Framework Aromatic homopolycyclic compounds
Substituents Alkyl-phenylketone - Naphthoquinone - Naphthalene - Acetophenone - Benzoyl - Quinone - Aryl alkyl ketone - Aniline or substituted anilines - Secondary aliphatic/aromatic amine - Monocyclic benzene moiety - Benzenoid - Alpha-haloketone - Vinylogous amide - Vinylogous halide - Alpha-chloroketone - Chloroalkene - Haloalkene - Enamine - Vinyl halide - Secondary amine - Vinyl chloride - Organohalogen compound - Organic nitrogen compound - Organochloride - Organonitrogen compound - Amine - Organic oxide - Organopnictogen compound - Hydrocarbon derivative - Aromatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group.
External Descriptors Not available

Associated Targets(Human)

PTPN6 Tchem Protein-tyrosine phosphatase 1C (687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-3 (638 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MRC5 (9203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504760149
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504760149
IUPAC Name 2-(4-acetylanilino)-3-chloronaphthalene-1,4-dione
INCHI InChI=1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3
InChIKey LSQZKIQSQHZVQS-UHFFFAOYSA-N
Smiles CC(=O)C1=CC=C(C=C1)NC2=C(C(=O)C3=CC=CC=C3C2=O)Cl
Isomeric SMILES CC(=O)C1=CC=C(C=C1)NC2=C(C(=O)C3=CC=CC=C3C2=O)Cl
Molecular Weight 325.75
Reaxy-Rn 9145649
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9145649&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
J2119399 Certificate of Analysis Aug 09, 2024 N288140
J2119405 Certificate of Analysis Aug 09, 2024 N288140
J2119408 Certificate of Analysis Aug 09, 2024 N288140
J2119414 Certificate of Analysis Aug 09, 2024 N288140
J2119416 Certificate of Analysis Aug 09, 2024 N288140

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 32.58, Max Conc. mM: 100
Molecular Weight 325.700 g/mol
XLogP3 2.900
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 3
Exact Mass 325.051 Da
Monoisotopic Mass 325.051 Da
Topological Polar Surface Area 63.200 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 561.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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