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Novobiocin Sodium - ≥95%, high purity , CAS No.1476-53-5

COA COA
    Grade & Purity:
  • ≥95%
In stock
Item Number
N129248
Grouped product items
SKU Size
Availability
 Price Qty
N129248-100mg
100mg
3
$79.90
N129248-250mg
250mg
3
$139.90
N129248-1g
1g
3
$399.90
N129248-5g
5g
2
$1,399.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Antibiotic. Potent, competitive DNA gyrase inhibitor.

View related series
Amino Acid/Protein Metabolism (1836) Anti-infection (2803) Antibiotic (1629) Apoptosis (4276) Bacterial (3013) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA Damage (697) DNA/RNA Synthesis (362) HSP (135) Metabolic Enzyme/Protease (4860) Orthopoxvirus (59) Virus (1811)

Basic Description

Synonyms EN300-123645 | HMS3656A08 | AS-57689 | Novobiocin (Sodium) | Albamycin;Cathomycin | HMS3374H11 | AKOS037645151 | Albamycinsodium | sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2
Specifications & Purity ≥95%
Biochemical and Physiological Mechanisms Novobiocin Sodium (U-6591) is a small molecule inhibitor of eukaryotic DNA topoisomerase II and prokaryotic DNA gyrase. In the case of DNA gyrase inhibition, Novobiocin functions as a competitive inhibitor of the ATP binding event necessary for turnover o
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Novobiocin Sodium is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of 14.87 ± 0.40 μM for hOAT1, 4.77 ± 1.12 μM for hOAT3 and 90.50 ± 7.50 μM for hOAT4.
An Hsp90 and DNA gyrase inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Coumarins and derivatives
Subclass Coumarin glycosides
Intermediate Tree Nodes Not available
Direct Parent Coumarin glycosides
Alternative Parents Phenolic glycosides  4-hydroxycoumarins  Hexoses  O-glycosyl compounds  1-benzopyrans  Benzamides  Benzoyl derivatives  Pyranones and derivatives  Phenoxides  Oxanes  Heteroaromatic compounds  Vinylogous acids  Lactones  Secondary alcohols  Secondary carboxylic acid amides  Oxacyclic compounds  Dialkyl ethers  Carboximidic acids and derivatives  Acetals  Organic sodium salts  Organic oxides  Organopnictogen compounds  Imines  Hydrocarbon derivatives  Organic zwitterions  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Coumarin o-glycoside - Coumarin-7-o-glycoside - Phenolic glycoside - 4-hydroxycoumarin - Hydroxycoumarin - Hexose monosaccharide - O-glycosyl compound - Glycosyl compound - 1-benzopyran - Benzopyran - Benzamide - Benzoic acid or derivatives - Benzoyl - Phenoxide - Pyranone - Benzenoid - Monocyclic benzene moiety - Monosaccharide - Oxane - Pyran - Vinylogous acid - Heteroaromatic compound - Lactone - Secondary carboxylic acid amide - Secondary alcohol - Carboxamide group - Acetal - Carboximidic acid derivative - Organoheterocyclic compound - Organic alkali metal salt - Dialkyl ether - Ether - Carboxylic acid derivative - Oxacycle - Organic nitrogen compound - Imine - Organonitrogen compound - Organooxygen compound - Organic zwitterion - Organic salt - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Alcohol - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as coumarin glycosides. These are aromatic compounds containing a carbohydrate moiety glycosidically bound to a coumarin moiety.
External Descriptors Not available

Associated Targets(Human)

A498 (42825 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 Activities)
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CCRF-CEM (65223 Activities)
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COLO 205 (50209 Activities)
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DU-145 (51482 Activities)
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HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM12 (47707 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M14 (47487 Activities)
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MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-3 (48710 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-5 (45555 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 393 (41971 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SN12C (47755 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-19 (46794 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TK-10 (45540 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-251 (51189 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-257 (46019 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-62 (47335 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UO-31 (46270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
786-0 (47912 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T47D (39041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EKVX (44102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H322M (45589 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC 2998 (41480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 Activities)
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SF-268 (49410 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IGROV-1 (47897 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HOP-62 (47048 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-N (28205 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Malme-3M (44254 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-75 (44215 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BT-549 (31254 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-539 (44845 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SR (39847 Activities)
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SW-620 (52400 Activities)
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Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504771387
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771387
IUPAC Name sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate
INCHI InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1
InChIKey WWPRGAYLRGSOSU-UHFFFAOYSA-M
Smiles CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
Isomeric SMILES CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
WGK Germany 2
RTECS RD5425000
PubChem CID 54730021
Molecular Weight 634.61
Beilstein 3892910

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number Certificate Type Date Item
G2221429 Certificate of Analysis Jun 12, 2024 N129248
G2221431 Certificate of Analysis May 21, 2024 N129248
G2221432 Certificate of Analysis May 21, 2024 N129248
G2221430 Certificate of Analysis May 21, 2024 N129248
C2405569 Certificate of Analysis Jan 30, 2024 N129248
C2405568 Certificate of Analysis Jan 30, 2024 N129248
C2405570 Certificate of Analysis Jan 30, 2024 N129248
C2405571 Certificate of Analysis Jan 30, 2024 N129248
A2212328 Certificate of Analysis Oct 16, 2023 N129248
A2212477 Certificate of Analysis Dec 24, 2021 N129248
A2212464 Certificate of Analysis Dec 24, 2021 N129248
A2212465 Certificate of Analysis Dec 24, 2021 N129248

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Chemical and Physical Properties

Solubility DMSO 127 mg/mL Water 127 mg/mL Ethanol 127 mg/mL
Melt Point(°C) 215°C
Molecular Weight 634.600 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 9
Exact Mass 634.214 Da
Monoisotopic Mass 634.214 Da
Topological Polar Surface Area 199.000 Ų
Heavy Atom Count 45
Formal Charge 0
Complexity 1160.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 4
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Alternative Products

  1. Novobiocin sodium, DNA gyrase inhibitor
    Novobiocin sodium, DNA gyrase inhibitor

    Starting at $389.90

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