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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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N133726-250mg
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250mg |
3
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$79.90
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N133726-1g
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1g |
2
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$219.90
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N133726-5g
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5g |
2
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$699.90
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Naturally occurring potent antioxidant
| Synonyms | NDGA | AC-24202 | HMS503G19 | Z2065671207 | 1, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis- | KBio2_004917 | KBio3_002828 | KBioSS_001626 | 4,4'-(2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) | NCGC00015741-09 | MLS000069451 | NCGC00015741-04 | nordihydrogu |
|---|---|
| Specifications & Purity | Moligand™, ≥95% |
| Biochemical and Physiological Mechanisms | Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.Naturally occurring potent antioxidant. Various pharmacological effects in vitro and in vivo . Anticancer, antimicrobial, anti-inflammatory and immunosuppressive activities. |
| Storage Temp | Store at 2-8°C,Argon charged |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Product Introduction Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS) Application Nordihydroguaiaretic acid can be used: In the synthesis of nordihydroguaiaretic acid derivatives with potent HIV inhibition activity;As a starting material in the synthesis of tetra-O-methylnordihydroguaiaretic acid. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lignans, neolignans and related compounds |
| Class | Dibenzylbutane lignans |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Dibenzylbutane lignans |
| Alternative Parents | Phenylpropanes Catechols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Dibenzylbutane lignan skeleton - Phenylpropane - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as dibenzylbutane lignans. These are lignan compounds containing a 2,3-dibenzylbutane moiety. |
| External Descriptors | a small molecule |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504750778 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750778 |
| IUPAC Name | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol |
| INCHI | InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 |
| InChIKey | HCZKYJDFEPMADG-UHFFFAOYSA-N |
| Smiles | CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O |
| Isomeric SMILES | CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O |
| WGK Germany | 3 |
| RTECS | UX1750000 |
| Molecular Weight | 302.37 |
| Beilstein | 6(1)577 |
| Reaxy-Rn | 9803564 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9803564&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 26, 2024 | N133726 | |
| Certificate of Analysis | Nov 26, 2024 | N133726 | |
| Certificate of Analysis | Apr 14, 2023 | N133726 | |
| Certificate of Analysis | Mar 14, 2023 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 | |
| Certificate of Analysis | Jun 02, 2022 | N133726 |
| Solubility | Soluble in 100% ethanol, methanol, acetone, dimethylsulfoxide, dimethylformamide, ethanol (5% w/v), glycol, PEG, and slightly soluble in hot water. Insoluble in water. |
|---|---|
| Sensitivity | Air sensitive |
| Melt Point(°C) | 184-188℃ |
| Molecular Weight | 302.400 g/mol |
| XLogP3 | 4.300 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 302.152 Da |
| Monoisotopic Mass | 302.152 Da |
| Topological Polar Surface Area | 80.900 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 303.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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