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Norathyriol - 99%, high purity , CAS No.3542-72-1

COA COA
    Grade & Purity:
  • ≥99%
In stock
Item Number
N649498
Grouped product items
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Availability
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N649498-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$214.90
N649498-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$450.90
N649498-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$800.90
N649498-25mg
25mg
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$1,650.90
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Phenols Polyphenols

View related series
Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Glucose Metabolism (1943) Glucosidase (71) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) Phenols Polyphenols (41) PPAR (155) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Synonyms AKOS028108772 | 1,3,6,7-Tetrahydroxyxanthone | AMY36806 | DTXSID30188901 | HY-N1029 | Norathyriol | NRA | BDBM50155447 | CHEBI:7622 | MS-23663 | Mangiferitin | 9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy- | Q27089365 | SCHEMBL2418732 | 1,3,6,7-Tetrahydroxyxant
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Norathyriol (Mangiferitin) is a natural metabolite of Mangifera . Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC 50 of 3.12u2009μM. Norathyriol inhibits PPARα , PPARβ , and PPARγ with IC 50 s of 92.8 µM, 102.4 µM, and 153.5
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC 50 of 3.12 μM. Norathyriol inhibits PPARα , PPARβ , and PPARγ with IC 50 s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively . Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

In Vitro

Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest. Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cellsCell Growth Assay\nWB MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mouse skin epidermal JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 24 or 72 hours Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death. Western Blot AnalysisCell Line: JB6 P+ cells Concentration: 0, 1, 10, or 25 µM Incubation Time: 2 hours Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

In Vivo

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety . Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult Kunming mice weighing 18-22 gDosage: 0.92, 1.85 and 3.7 mg/kg Administration: Administered intragastrically; twice daily for five times Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzopyrans
Subclass 1-benzopyrans
Intermediate Tree Nodes Dibenzopyrans - Xanthenes
Direct Parent Xanthones
Alternative Parents Chromones  Pyranones and derivatives  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Vinylogous acids  Heteroaromatic compounds  Polyols  Oxacyclic compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Xanthone - Chromone - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Pyran - Benzenoid - Heteroaromatic compound - Vinylogous acid - Polyol - Oxacycle - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
External Descriptors xanthenes

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
XDH Tclin Xanthine dehydrogenase (1038 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FASN Tchem Fatty acid synthase (3390 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MMP12 Tchem Matrix metalloproteinase 12 (1130 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 320 (353 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KB (17409 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase (280 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mmp13 Matrix metalloproteinase 13 (19 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp2 Matrix metalloproteinase-2 (12 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Salmonella typhi (4293 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Shigella sonnei (625 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man1 Alpha-mannosidase (188 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FUCA1 Alpha-L-fucosidase 1 (358 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 1,3,6,7-tetrahydroxyxanthen-9-one
INCHI InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H
InChIKey ZHTQCPCDXKMMLU-UHFFFAOYSA-N
Smiles C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O
Isomeric SMILES C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O
Alternate CAS 3542-72-1
PubChem CID 5281656
MeSH Entry Terms norathyriol
Molecular Weight 260.20

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility DMSO : 100 mg/mL (384.32 mM; Need ultrasonic) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Molecular Weight 260.200 g/mol
XLogP3 2.100
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 0
Exact Mass 260.032 Da
Monoisotopic Mass 260.032 Da
Topological Polar Surface Area 107.000 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 372.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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