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NKL 22 - 95%, high purity , CAS No.537034-15-4

1 Citations COA COA
    Grade & Purity:
  • ≥95%
In stock
Item Number
N338203
Grouped product items
SKU Size
Availability
 Price Qty
N338203-5mg
5mg
3
$35.90
N338203-10mg
10mg
2
$58.90
N338203-25mg
25mg
2
$132.90
N338203-50mg
50mg
2
$236.90
N338203-100mg
100mg
2
$434.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

an HDAC inhibitor

View related series
Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Epigenetics (1496) HDAC (160) Histone Modification (1379)

Basic Description

Synonyms Histone Deacetylase Inhibitor IV | DTXSID60429495 | NKL-22 | Probes2_000492 | HY-100384 | BDBM50254774 | NKL 22 | N-(2-Aminophenyl)-N inverted exclamation mark -phenylheptanediamide | FT-0662016 | PAOA | A923366 | BCP16847 | N11287 | s6548 | AKOS027439961
Specifications & Purity ≥95%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Product description：

NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrationsNKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes.HDAC inhibitors act directly on FXN.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Anilides
Intermediate Tree Nodes Not available
Direct Parent 2'-Aminoanilides
Alternative Parents N-arylamides  Aniline and substituted anilines  Fatty amides  Secondary carboxylic acid amides  Amino acids and derivatives  Primary amines  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic homomonocyclic compounds
Substituents 2'-aminoanilide - N-arylamide - Aniline or substituted anilines - Fatty amide - Fatty acyl - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Amine - Carbonyl group - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as 2'-aminoanilides. These are organic compounds containing an anilide moieties that carries an amino group at the 2-position of the benzene ring.
External Descriptors Not available

Product Properties

pKa pKₐ: 4.04 (Predicted)

Associated Targets(Human)

HDAC1 Tclin Histone deacetylase 1 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC3 Tclin Histone deacetylase 3 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC8 Tclin Histone deacetylase 8 (4516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC2 Tclin Histone deacetylase 2 (3971 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC3 Tclin Histone deacetylase 3 (3654 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC4 Tclin Histone deacetylase 4 (2328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC7 Tclin Histone deacetylase 7 (1047 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-937 (7138 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC3 Tclin Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (735 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GM15850 (303 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac1 Histone deacetylase 1 (93 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac5 Histone deacetylase 5 (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HD1 Histone deacetylase (38 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764795
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764795
IUPAC Name N'-(2-aminophenyl)-N-phenylheptanediamide
INCHI InChI=1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
InChIKey ZAIULUYKQLVQFH-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N
Isomeric SMILES C1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N
Molecular Weight 325.4
Reaxy-Rn 9424961
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9424961&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
A2312360 Certificate of Analysis Sep 26, 2022 N338203
A2312344 Certificate of Analysis Sep 26, 2022 N338203
A2312326 Certificate of Analysis Sep 26, 2022 N338203
A2312345 Certificate of Analysis Sep 26, 2022 N338203
A2312346 Certificate of Analysis Sep 26, 2022 N338203

Chemical and Physical Properties

Solubility Soluble in DMSO (100 mg/ml), and methanol (5 mg/ml).
Refractive Index n20D1.64 (Predicted)
Boil Point(°C) 627.86° C at 760 mmHg (Predicted)
Melt Point(°C) 159-161° C (lit.)
Molecular Weight 325.400 g/mol
XLogP3 2.400
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 8
Exact Mass 325.179 Da
Monoisotopic Mass 325.179 Da
Topological Polar Surface Area 84.200 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 394.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. N-(2-Aminophenyl)-N′-phenylheptanediamide
    N-(2-Aminophenyl)-N′-phenylheptanediamide
    • 10mM in DMSO

    Starting at $241.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yutao Yang, Caixia Yin, Fangjun Huo, Jianbin Chao, Yongbin Zhang.  (2014)  Highly selective relay recognition of hydrogen sulfide and Hg(II) by a commercially available fluorescent chemosensor and its application in bioimaging.  SENSORS AND ACTUATORS B-CHEMICAL,  204  (402). 

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