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Nizatidine - 10mM in DMSO, high purity , CAS No.76963-41-2
Basic Description
Synonyms
nizatidine | 76963-41-2 | Axid | Zanizal | Nizax | LY-139037 | ZE-101 | ZL-101 | (E)-N-(2-(((2-((dimethylamino)methyl)thiazol-4-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine | NCGC00016934-01 | CAS-76963-41-2 | Niaztidine | (E)-N-(2-(((2-((dimethylamino)methyl)thiazo
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Nizatidine is a histamine H2 receptor antagonist which functions as a potent inhibitor of gastric acid secretion.Selective H 2 antagonist (IC 50 = 6.7 µM). Inhibits gastric acid secretion. Water-soluble. Active in vitro and in vivo .
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Product Description
Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Azoles
Subclass
Thiazoles
Intermediate Tree Nodes
Not available
Direct Parent
2,4-disubstituted thiazoles
Alternative Parents
Aralkylamines Heteroaromatic compounds Trialkylamines C-nitro compounds Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Dialkylthioethers Dialkylamines Azacyclic compounds Organopnictogen compounds Organic zwitterions Organic oxides Hydrocarbon derivatives
Molecular Framework
Aromatic heteromonocyclic compounds
Substituents
2,4-disubstituted 1,3-thiazole - Aralkylamine - Heteroaromatic compound - Tertiary aliphatic amine - C-nitro compound - Tertiary amine - Organic nitro compound - Azacycle - Secondary amine - Dialkylthioether - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organic oxoazanium - Sulfenyl compound - Secondary aliphatic amine - Thioether - Organic nitrogen compound - Organic zwitterion - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic heteromonocyclic compound
Description
This compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
(E)-1-N'-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
INCHI
InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
InChIKey
SGXXNSQHWDMGGP-IZZDOVSWSA-N
Smiles
CNC(=C[N+](=O)[O-])NCCSCC1=CSC(=N1)CN(C)C
Isomeric SMILES
CN/C(=C\[N+](=O)[O-])/NCCSCC1=CSC(=N1)CN(C)C
RTECS
KM6565000
Molecular Weight
331.46
Reaxy-Rn
4846056
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4846056&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
Air sensitive
Melt Point(°C)
133-134°C
Molecular Weight
331.500 g/mol
XLogP3
1.600
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Rotatable Bond Count
9
Exact Mass
331.114 Da
Monoisotopic Mass
331.114 Da
Topological Polar Surface Area
140.000 Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
349.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
1
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
1
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Guodong Shan, Xiuqin Fan, Qingcheng Wang, Li Zhang, Lijun Ge, Weibo Lu, Jing Xue, Kang Chen, Zejun Wang, Qing Shen.
(2025)
Development of a Captiva EMR-lipid clean-up and LC-MS/MS methodology for detecting H2 receptor antagonists in functional foods and food-medicine homology materials. Applied Food Research,
5
(100772).
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1 Citations