The store will not work correctly when cookies are disabled.
This is a demo store. No orders will be fulfilled.
We use cookies to keep things working smoothly and to improve your experience.
Choose what’s okay for you below. See our Cookie Policy.
Nimesulide - 10mM in DMSO, high purity , CAS No.51803-78-2(DMSO), Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2
COX-2 Selective Inhibitors
Basic Description
| Synonyms |
N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide |
| Specifications & Purity |
Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms |
Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM. |
| Storage Temp |
Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade |
Moligand™ |
| Action Type |
INHIBITOR |
| Mechanism of action |
Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2 |
| Product Description |
Information Nimesulide is a relativelyCOX-2selective inhibitor withIC50of 26 μM.
In vitro
In vivo
Cell Data
cell lines：HepG2 cells Concentrations： Incubation Time： Powder Purity:≥99%
|
Product Properties
| ALogP |
2.195 |
| hba_count |
3 |
| HBD Count |
1 |
| Rotatable Bond |
5 |
Associated Targets(Human)
Names and Identifiers
| Smiles |
C[S](=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O |
| Molecular Weight |
308.31 |
| Reaxy-Rn |
2421175 |
| Reaxys-RN_link_address |
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2421175&ln= |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
| Solubility |
Solubility (25°C) In vitro DMSO: 66 mg/mL (198.11 mM); Ethanol: -1 mg/mL |
| DMSO(mg / mL) Max Solubility |
62 |
| DMSO(mM) Max Solubility |
201.1 |
| Water(mg / mL) Max Solubility |
<1 |
Citations of This Product
|
1.
Rongzheng Liu, Xin Wang, Na Fan, Hang Song, Pingping Ma, Chang Li, Jing Li, Jin Sun.
(2021)
Superiority of Chiral-handed mesoporous silica nanoparticles in delivering Nimesulide.
Materials Science and Engineering B-Advanced Functional Solid-State Materials,
269
(115161).
|
|
2.
Wei Liu, Jiabin Zhou, Ying Zhou, Dan Liu.
(2021)
Peroxymonosulfate-assisted g-C3N4@Bi2MoO6 photocatalytic system for degradation of nimesulide through phenyl ether bond cleavage under visible light irradiation.
SEPARATION AND PURIFICATION TECHNOLOGY,
264
(118288).
|
|
3.
Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang.
(2021)
Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples.
ANALYST,
146
(3):
(874-881).
|
|
4.
Zhongxia WANG, Yuanfei GAO, Wenjuan WANG, Fenying KONG, Hengye LI, Dahe FAN, Wei WANG.
(2020)
On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet.
ANALYTICAL SCIENCES,
36
(11):
(1379-1385).
|
|
5.
Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu.
(2020)
A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states.
SENSORS AND ACTUATORS B-CHEMICAL,
324
(128696).
|
|
6.
Zhongjuan Wang, Li-chao Nengzi, Xinyi Zhang, Zhuanjun Zhao, Xiuwen Cheng.
(2020)
Novel NiCo2S4/CS membranes as efficient catalysts for activating persulfate and its high activity for degradation of nimesulide.
CHEMICAL ENGINEERING JOURNAL,
381
(122517).
|
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
Shall we send you a message when we have discounts available?
Remind me later
Thank you! Please check your email inbox to confirm.
Oops! Notifications are disabled.
6 Citations