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Nicardipine hydrochloride - 10mM in DMSO, high purity , CAS No.54527-84-3
L-type Ca 2+ channel antagonist
Basic Description
Synonyms
NICARDIPINE HYDROCHLORIDE | 54527-84-3 | Nicardipine HCl | Cardene | Perdipine | Nicodel | Loxen | Perdipina | YC-93 | Angioglebil | Bionicard | Nicardil | Vasonase | Dafil | Nicardipine (Hydrochloride) | Dagan | Barizin | Cardepine | Dacarel | Lecibra | Lecibral | Lescodil | Nerdipina | Nicapress | Ni
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Selective, L-type Ca 2+ channel blocker (IC 50 = 24.1 μM). Dihydropyridine derivative. Potent coronary and cerebral vasodilator.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Nicardipine hydrochloride is the hydrochloride salt preparation of Nicardipine and a potent L-type calcium channel protein inhibitor. Nicardipine is described to alter cytochrome P-450 3A expression through induction of CYP3A. Nicardipine blockade of Ca2+ channels has been correlated to antihypertensive effects.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Pyridines and derivatives
Subclass
Hydropyridines
Intermediate Tree Nodes
Dihydropyridines
Direct Parent
Dihydropyridinecarboxylic acids and derivatives
Alternative Parents
Nitrobenzenes Phenylmethylamines Benzylamines Nitroaromatic compounds Aralkylamines Dicarboxylic acids and derivatives Vinylogous amides Enoate esters Methyl esters Trialkylamines Amino acids and derivatives Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Dialkylamines Organic oxoazanium compounds Enamines Organopnictogen compounds Organic zwitterions Carbonyl compounds Organic oxides Hydrocarbon derivatives Hydrochlorides
Molecular Framework
Aromatic heteromonocyclic compounds
Substituents
Dihydropyridinecarboxylic acid derivative - Nitrobenzene - Benzylamine - Nitroaromatic compound - Phenylmethylamine - Aralkylamine - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Benzenoid - Vinylogous amide - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Methyl ester - Amino acid or derivatives - Organic nitro compound - Carboxylic acid ester - C-nitro compound - Tertiary amine - Tertiary aliphatic amine - Azacycle - Carboxylic acid derivative - Secondary aliphatic amine - Organic 1,3-dipolar compound - Enamine - Propargyl-type 1,3-dipolar organic compound - Organic oxoazanium - Secondary amine - Allyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Hydrochloride - Carbonyl group - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organic oxide - Amine - Organic zwitterion - Aromatic heteromonocyclic compound
Description
This compound belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. These are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Names and Identifiers
IUPAC Name
5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride
INCHI
InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
InChIKey
AIKVCUNQWYTVTO-UHFFFAOYSA-N
Smiles
CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl
Isomeric SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl
WGK Germany
3
RTECS
US7972100
Molecular Weight
515.99
Reaxy-Rn
4286471
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4286471&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
Light sensitive
Molecular Weight
516.000 g/mol
XLogP3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Rotatable Bond Count
10
Exact Mass
515.182 Da
Monoisotopic Mass
515.182 Da
Topological Polar Surface Area
114.000 Ų
Heavy Atom Count
36
Formal Charge
0
Complexity
856.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
2
Citations of This Product
1.
Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo.
(2024)
Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS,
126
(105825).
2.
Wei Dong, Qin Zhou, Wangqiang Shen, Le Yang, Peng Jin, Xing Lu, Yongfu Lian.
(2023)
The Various Packing Structures of Tb@C82 (I, II) Isomers in Their Cocrystals with Ni(OEP). Nanomaterials,
13
(6):
(994).
3.
Xin Song, Jiangle An, Chao He, Jukai Zhou, Yuanting Xu, Haifeng Ji, Li Yang, Jiarui Yin, Weifeng Zhao, Changsheng Zhao.
(2019)
A bioinspired strategy towards super-adsorbent hydrogel spheres via self-sacrificing micro-reactors for robust wastewater remediation. Journal of Materials Chemistry A,
7
(37):
(21386-21403).
4.
Sun Fu-Hua, Dong Jinfeng, Tang Huaichao, Zhuang
Hua-Lu, Li Jing-Feng.
(2019)
ZnO-Nanoparticle-Dispersed Cu11.5Ni0.5Sb4S13−δ Tetrahedrite Composites with Enhanced Thermoelectric Performance. JOURNAL OF ELECTRONIC MATERIALS,
48
(4):
(1840-1845).
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4 Citations