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Nexturastat A - 98%, high purity , CAS No.1403783-31-2, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 6

COA COA
In stock
Item Number
N349054
Grouped product items
SKU Size
Availability
 Price Qty
N349054-1mg
1mg
3
$77.90
N349054-5mg
5mg
3
$116.90
N349054-25mg
25mg
2
$526.90
N349054-100mg
100mg
2
$597.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Epigenetics (1496) HDAC (160) histone deacetylase 1 Inhibitor (31) histone deacetylase 6 Inhibitor (33) Histone Modification (1379)

Basic Description

Synonyms MFCD28099804 | AKOS026750221 | Nexturastat A | Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy- | 4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide | N4R | SCHEMBL15289693 | BDBM50398716 | FT-0700450 | s7473 | J-690165 | NCGC0016192
Specifications & Purity Moligand™, ≥98%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 6
Product Description

Product Describtion:
Nexturastat A is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 value of 5 nM.

Product Application：

In B16 murine melanoma cells, Nexturastat A dose-dependently elevated acetyl α-tubulin levels without increasing histone H3 acetylation. Moreover, Nexturastat A potently inhibited the growth of B16 melanoma cells, with the GI50 value of 14.3 μM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass N-phenylureas
Intermediate Tree Nodes Not available
Direct Parent N-phenylureas
Alternative Parents Benzoic acids and derivatives  Benzoyl derivatives  Ureas  Hydroxamic acids  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic homomonocyclic compounds
Substituents N-phenylurea - Benzoic acid or derivatives - Benzoyl - Urea - Hydroxamic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group.
External Descriptors Not available

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (15 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC1 Tclin Histone deacetylase 1 (7 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC2 Tclin Histone deacetylase 2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC10 Tclin Histone deacetylase 10 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC8 Tclin Histone deacetylase 8 (4 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HDAC8 Tclin Histone deacetylase 8 (4516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC10 Tclin Histone deacetylase 10 (801 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC2 Tclin Histone deacetylase 2 (3971 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC3 Tclin Histone deacetylase 3 (3654 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC4 Tclin Histone deacetylase 4 (2328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC9 Tclin Histone deacetylase 9 (708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC11 Tclin Histone deacetylase 11 (967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC7 Tclin Histone deacetylase 7 (1047 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
5637 (630 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T-24 (2342 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MV4-11 (7307 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
697 (196 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HDAC6 Tclin Cereblon/Histone deacetylase 6 (114 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MM1.S (1111 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac1 Histone deacetylase 1 (93 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac5 Histone deacetylase 5 (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HD1 Histone deacetylase (38 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
B16 (5829 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772119
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772119
IUPAC Name 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
INCHI InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
InChIKey JZWXMCPARMXZQV-UHFFFAOYSA-N
Smiles CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2
Isomeric SMILES CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2
Molecular Weight 341.4
Reaxy-Rn 23135477
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23135477&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
H2213259 Certificate of Analysis May 13, 2025 N349054
H2213258 Certificate of Analysis May 13, 2025 N349054
H2213255 Certificate of Analysis May 13, 2025 N349054
H2213254 Certificate of Analysis May 13, 2025 N349054
C2508166 Certificate of Analysis Jun 14, 2022 N349054

Chemical and Physical Properties

Solubility insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH
Molecular Weight 341.400 g/mol
XLogP3 2.600
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 7
Exact Mass 341.174 Da
Monoisotopic Mass 341.174 Da
Topological Polar Surface Area 81.700 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 416.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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