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NEO2734 - 98%, high purity , CAS No.2081072-29-7

COA

Grade & Purity:

≥98%

Cas Number: 2081072-29-7
Molecular Weight: 435.44
PubChem CID: 126582741
PubChem SID: 504773015

In stock

Item Number

N414442

Grouped product items
SKU	Size	Availability	Price
N414442-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$98.90
N414442-5mg	5mg	2	$345.90
N414442-10mg	10mg	3	$573.90
N414442-25mg	25mg	2	$1,291.90
N414442-50mg	50mg	2	$1,632.90

Histone Acetyltransferase Inhibitors

View related series

Epigenetic Reader Domain (314) Epigenetics (1496) Histone Acetyltransferase (79) Histone Modification (1379)

Basic Description

Synonyms	EP316702 \| 1,3-dimethyl-5-[2-(tetrahydro-2H-pyran-4-yl)-1-[2-(trifluoromethoxy)ethyl]-1H-benzimidazol-6-yl]- (1H)-Pyridinone
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information NEO2734 NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM. Targets p300/CBP (Cell-free assay); BET (Cell-free assay) <30 nM; <30 nM In vitro Treatment of NMC cells with the novel dual p300/CBP and BET bromodomain–selective inhibitor, NEO2734, potently inhibits growth and induces differentiation of NMC cells in vitro; findings that correspond with potentiated transcriptional effects from combined BET and p300 bromodomain inhibition. In vivo In three disseminated NMC xenograft models, NEO2734 provides greater growth inhibition, with tumor regression and significant survival benefit seen in two of three models, compared with a lead clinical BET inhibitor or “standard” chemotherapy. Cell Research(from reference) Cell lines：NUT carcinoma patient cell lines (TC-797, 14169, 10-15, PER-403) Concentrations：1 μM Incubation Time：24 h

Names and Identifiers

Pubchem Sid	504773015
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773015
IUPAC Name	1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethoxy)ethyl]benzimidazol-5-yl]pyridin-2-one
INCHI	InChI=1S/C22H24F3N3O3/c1-14-11-17(13-27(2)21(14)29)16-3-4-18-19(12-16)28(7-10-31-22(23,24)25)20(26-18)15-5-8-30-9-6-15/h3-4,11-13,15H,5-10H2,1-2H3
InChIKey	KPWWFNXRLAAREN-UHFFFAOYSA-N
Smiles	CC1=CC(=CN(C1=O)C)C2=CC3=C(C=C2)N=C(N3CCOC(F)(F)F)C4CCOCC4
Molecular Weight	435.44
Reaxy-Rn	30909951
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30909951&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
F2218453	Certificate of Analysis	Apr 03, 2025	N414442
F2218315	Certificate of Analysis	Apr 03, 2025	N414442
F2218316	Certificate of Analysis	Apr 03, 2025	N414442
F2218337	Certificate of Analysis	Apr 03, 2025	N414442

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 87 mg/mL (199.79 mM); Ethanol: 87 mg/mL (199.79 mM); Water: Insoluble;
Molecular Weight	435.400 g/mol
XLogP3	2.900
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	435.177 Da
Monoisotopic Mass	435.177 Da
Topological Polar Surface Area	56.600 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	733.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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