Skip to the beginning of the images gallery

Nefiracetam - ≥98%, high purity , CAS No.77191-36-7

COA

Grade & Purity:

≥98%

Cas Number: 77191-36-7
Molecular Weight: 246.3
MDL number: MFCD00209882
PubChem CID: 71157
PubChem SID: 504754607

In stock

Item Number

N129604

Grouped product items
SKU	Size	Availability	Price
N129604-50mg	50mg	3	$53.90
N129604-250mg	250mg	3	$218.90
N129604-1g	1g	2	$787.90
N129604-5g	5g	2	$1,599.90

Nootropic agent. Potent ACh and NMDA agonist.

View related series

GABA Receptor (181) Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) Pharmaceutical ingredients (367)

Basic Description

Synonyms	DM 9384 \| INF 4668 \| N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl]acetamide \| Tox21_113521 \| AC-32883 \| Q6039388 \| DTXSID2020923 \| NEFIRACETAM [MART.] \| T72927 \| KS-5226 \| Motiva \| Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate \| Tox21_113521_1 \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Nefiracetam is a nootropic of the racetam family. Nefiracetam is cognitive enhancer with an IC50 of approximately 150–200 μM for Ro 5-4864. This compound activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Nefiracetam di
Shipped In	Normal
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Activator of L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives
Direct Parent	Alpha amino acids and derivatives
Alternative Parents	Anilides m-Xylenes N-arylamides Pyrrolidine-2-ones N-alkylpyrrolidines Tertiary carboxylic acid amides Secondary carboxylic acid amides Lactams Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Alpha-amino acid or derivatives - Anilide - N-arylamide - Xylene - M-xylene - 2-pyrrolidone - Monocyclic benzene moiety - Benzenoid - N-alkylpyrrolidine - Pyrrolidone - Pyrrolidine - Tertiary carboxylic acid amide - Secondary carboxylic acid amide - Lactam - Carboxamide group - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

Discover Target: PIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504754607
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504754607
IUPAC Name	N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
INCHI	InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChIKey	NGHTXZCKLWZPGK-UHFFFAOYSA-N
Smiles	CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O
Isomeric SMILES	CC1=C(C(=CC=C1)C)NC(=O)CN2CCCC2=O
WGK Germany	3
RTECS	UX9655650
Molecular Weight	246.3
Reaxy-Rn	6848330
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6848330&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
G1524096	Certificate of Analysis	Jan 14, 2025	N129604
C2406398	Certificate of Analysis	Mar 12, 2024	N129604
C2406400	Certificate of Analysis	Mar 12, 2024	N129604
C2406403	Certificate of Analysis	Mar 12, 2024	N129604

Chemical and Physical Properties

Solubility	Soluble in DMSO (49 mg/ml at 25 °C), water (5 mg/ml at 25 °C), and ethanol (49 mg/ml at 25 °C).
Melt Point(°C)	151 °C
Molecular Weight	246.300 g/mol
XLogP3	1.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	246.137 Da
Monoisotopic Mass	246.137 Da
Topological Polar Surface Area	49.400 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	320.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration