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Nampt-IN-5 - 99%, high purity , CAS No.2380013-17-0

COA

Grade & Purity:

≥99%

Cas Number: 2380013-17-0
Molecular Weight: 427.50
PubChem CID: 146014464

In stock

Item Number

N651584

Grouped product items
SKU	Size	Availability	Price
N651584-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90
N651584-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
N651584-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$680.90
N651584-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90
N651584-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,200.90
N651584-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,400.90

View related series

Cytochrome P450 (241) Glucose Metabolism (1943) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) NAMPT (29)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively In Vitro Nampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min•mg), CYP3A4 inhibition value (0.75 μM), Sol 6.8 : 0.056 mM; MDCK P app AB: 18.6. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Nampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle . Nampt-IN-5 (10 mg/kg; p.o.) exhibits T 1/2 (2.1 h), C max (29112 nM), and AUC (61984 nM•h) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:NAMPT, CYP3A4

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass N-phenylureas

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	N-phenylureas
Intermediate Tree Nodes	Not available
Direct Parent	N-phenylureas
Alternative Parents	Benzimidazoles Methylpyridines Alkyl aryl ethers N-substituted imidazoles Heteroaromatic compounds Organic carbonic acids and derivatives Azetidines Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-phenylurea - Benzimidazole - Methylpyridine - Alkyl aryl ether - Pyridine - N-substituted imidazole - Heteroaromatic compound - Azole - Carbonic acid derivative - Azetidine - Azacycle - Organoheterocyclic compound - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

COR-L23 (253 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-[4-[(2-ethoxybenzimidazol-1-yl)methyl]phenyl]-3-pyridin-3-ylazetidine-1-carboxamide
INCHI	InChI=1S/C25H25N5O2/c1-2-32-25-28-22-7-3-4-8-23(22)30(25)15-18-9-11-21(12-10-18)27-24(31)29-16-20(17-29)19-6-5-13-26-14-19/h3-14,20H,2,15-17H2,1H3,(H,27,31)
InChIKey	JWEBCHOGBDMGBY-UHFFFAOYSA-N
Smiles	CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5
Isomeric SMILES	CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5
PubChem CID	146014464
Molecular Weight	427.50

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