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Nampt-IN-10 TFA , CAS No.2567724-20-1

COA

Cas Number: 2567724-20-1

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Item Number

N649749

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SKU	Size	Availability	Price
N649749-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$120.90
N649749-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90
N649749-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90
N649749-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$610.90
N649749-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$980.90

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Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) NAMPT (29)

Basic Description

Biochemical and Physiological Mechanisms	Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC 50 s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antim
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC 50 s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs In Vitro Nampt-IN-10 TFA (0-1 μM; 72 h) shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines Concentration: 0-1 μM Incubation Time: 72 hours Result: Showed cellular potency towards A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC 50 values of 5, 19, 2, 0.4 and 1 nM, respectively. Form:Solid IC50& Target:IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)

Names and Identifiers

Smiles	FC(C=C1NC([C@@H]2[C@@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O.OC(C(F)(F)F)=O.[x]

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