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Nampt activator-2 - 98%, high purity , CAS No.2237268-90-3

COA

Grade & Purity:

≥98%

Cas Number: 2237268-90-3
Molecular Weight: 390.84

In stock

Item Number

N647016

Grouped product items
SKU	Size	Availability	Price
N647016-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
N647016-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
N647016-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90

View related series

Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) NAMPT (29)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC 50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC 50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM). In Vitro Nampt activator-2 (compound 34) (10 μM, 4 h) results in a marked increase of both NMN and NAD in A549 lung epithelial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Nampt activator-2 (compound 34) (1 mg/kg iv and 10 mg/kg po, once) shows low plasma clearance, good exposure and excellent oral bioavailability (%F = 80) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mouse Dosage: 1 mg/kg iv and 10 mg/kg po Administration: IV, PO; once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of Nampt activator-2 in mouse . IV (1 mg/kg) PO (10 mg/kg) C max (ng/mL) 9550 AUC 0-24 (ng/mL∗h) 54463 t 1/2 (h) 3.2 CL (mL/min/kg) 3 Vd (L/kg) 0.61 F (%) 80 Form:Solid

Names and Identifiers

Smiles	O=C(NCC1=CNN=C1)NC2=CC=C(S(=O)(C3=CC=C(C=C3)Cl)=O)C=C2
Molecular Weight	390.84

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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