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MZP-55 - 10mM in DMSO, high purity , CAS No.2010159-48-3(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 2010159-48-3(DMSO)
Molecular Weight: 1080.72

In stock

Item Number

M655730

Grouped product items
SKU	Size	Availability	Price	Qty
M655730-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$605.90

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Compound libraries (12325) Epigenetic Reader Domain (314) Epigenetics (1496) PROTAC (2077) PROTACs (183)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	MZP-55 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4 , with a K d of 8 nM for Brd4 BD2 .
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	MZP-55 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4 , with a K d of 8 nM for Brd4 BD2 . In Vitro MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a K d of 8 nM for Brd4 BD2 . MZP-55 binds to VHL-EloC-EloB protein (VCB) with a K d of 105 ± 24 nM. MZP-55 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC 50 s of 7.31 ± 0.03 and 6.57 ± 0.02, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Kd: 8 nM (Brd4 BD2 )

Associated Targets(Human)

BRD4 Tchem Bromodomain-containing protein 4 (1 Activities)

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)NCCOCCOCCOCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)NC7=CC=C(C=C7)Cl
Molecular Weight	1080.72

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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