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Myrislignan - 98%, high purity , CAS No.171485-39-5

COA

Grade & Purity:

≥98%

Cas Number: 171485-39-5
Molecular Weight: 374.43
PubChem CID: 21636106
PubChem SID: 488199898

In stock

Item Number

M412873

Grouped product items
SKU	Size	Availability	Price
M412873-1mg	1mg	5	$17.90
M412873-5mg	5mg	4	$74.90
M412873-25mg	25mg	2	$308.90
M412873-50mg	50mg	1	$513.90
M412873-100mg	100mg	1	$925.90

TNF-α Selective Inhibitors | Activators | Antagonists

View related series

NF-κB (747)

Basic Description

Synonyms	Q-100206 \| 4-((1R,2S)-2-(4-Allyl-2,6-dimethoxyphenoxy)-1-hydroxypropyl)-2-methoxyphenol \| AC-34668 \| FT-0688337 \| HY-N0608 \| AS-77374 \| s3261 \| BDBM50242967 \| MFCD13195532 \| Myrislignan \| AKOS015909818 \| (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO syntha
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Myrislignan, a lignan isolated fromMyristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibitsinterleukin-6 (IL-6)andtumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions ofinducible NO synthase (iNOS)andcyclooxygenase-2 (COX-2)dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits theNF-κBsignalling pathway activation. Targets IL-6 ; TNF-α ; iNOS ; COX-2 ; NF-κB

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lignans, neolignans and related compounds

Kingdom	Organic compounds
Superclass	Lignans, neolignans and related compounds
Class	Not available
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Lignans, neolignans and related compounds
Alternative Parents	Methoxyphenols Dimethoxybenzenes Phenylpropanes Phenoxy compounds Anisoles Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Secondary alcohols Hydrocarbon derivatives Aromatic alcohols
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Neolignan skeleton - Methoxyphenol - Dimethoxybenzene - M-dimethoxybenzene - Phenylpropane - Methoxybenzene - Anisole - Phenoxy compound - Phenol ether - Alkyl aryl ether - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Secondary alcohol - Ether - Alcohol - Hydrocarbon derivative - Aromatic alcohol - Organic oxygen compound - Organooxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as lignans, neolignans and related compounds. These are plant products of low molecular weight formed primarily from oxidative coupling of two p-propylphenol moieties. They can also be described as micromolecules with two phenylpropanoid units coupled together. They can be attached in various manners, like C5-C5', C8-C8'. Most known natural lignans are oxidized at C9 and C9´ and, based upon the way in which oxygen is incorporated into the skeleton and on the cyclization patterns, a wide range of lignans of very different structural types can be formed.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	3.98
hba_count	4
HBD Count	2
Rotatable Bond	9

Associated Targets(non-human)

Toxoplasma gondii (4585 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488199898
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488199898
IUPAC Name	4-[(1R,2S)-2-(2,6-dimethoxy-4-prop-2-enylphenoxy)-1-hydroxypropyl]-2-methoxyphenol
INCHI	InChI=1S/C21H26O6/c1-6-7-14-10-18(25-4)21(19(11-14)26-5)27-13(2)20(23)15-8-9-16(22)17(12-15)24-3/h6,8-13,20,22-23H,1,7H2,2-5H3/t13-,20-/m0/s1
InChIKey	ULZFTGWWPHYLGI-RBZFPXEDSA-N
Smiles	CC(C(C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC
Isomeric SMILES	C[C@@H]([C@@H](C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC
Molecular Weight	374.43
Reaxy-Rn	2019083
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2019083&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
D23141982	Certificate of Analysis	Mar 06, 2023	M412873
D23142026	Certificate of Analysis	Mar 06, 2023	M412873
D23142122	Certificate of Analysis	Mar 06, 2023	M412873
D23141944	Certificate of Analysis	Mar 06, 2023	M412873
D23141954	Certificate of Analysis	Mar 06, 2023	M412873
D23142013	Certificate of Analysis	Mar 06, 2023	M412873
D23142029	Certificate of Analysis	Mar 06, 2023	M412873
D23141983	Certificate of Analysis	Mar 06, 2023	M412873
D23142034	Certificate of Analysis	Mar 06, 2023	M412873
D23141988	Certificate of Analysis	Mar 06, 2023	M412873

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (267.07 mM);
Sensitivity	Light sensitive
DMSO(mg / mL) Max Solubility	100
DMSO(mM) Max Solubility	267.072617044574
Water(mg / mL) Max Solubility	-1
Molecular Weight	374.400 g/mol
XLogP3	3.800
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	374.173 Da
Monoisotopic Mass	374.173 Da
Topological Polar Surface Area	77.400 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	430.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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