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MYF-01-37 - 10mM in DMSO, high purity , CAS No.2416417-65-5
Basic Description
Synonyms
1-(3-(3-(trifluoromethyl)phenylamino)-3-methylpyrrolidin-1-yl)prop-2-en-1-one
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Information
MYF-01-37 MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
Targets
TEAD
In vitro
MYF-01-37 is developed as a covalent binder to TEAD, targeting Cys380 when incubated with the TEAD2 protein (C359 in TEAD1). Pretreating cells with MYF-01-37 leads to loss of direct TEAD pull-down by biotin-MYF-01-037 from whole-cell lysate, confirming MYF-01-037 binding to TEAD in cells.
Cell Research(from reference)
Cell lines：PC9 cells
Concentrations：10 μM, 1 μM
Incubation Time：6 h
Names and Identifiers
IUPAC Name
1-[3-methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one
INCHI
InChI=1S/C15H17F3N2O/c1-3-13(21)20-8-7-14(2,10-20)19-12-6-4-5-11(9-12)15(16,17)18/h3-6,9,19H,1,7-8,10H2,2H3
InChIKey
MTBDEVWWJBIUOK-UHFFFAOYSA-N
Smiles
CC1(CCN(C1)C(=O)C=C)NC2=CC=CC(=C2)C(F)(F)F
Molecular Weight
298.3
Reaxy-Rn
36048179
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36048179&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Solubility
Solubility (25°C) In vitro DMSO: 60 mg/mL (201.13 mM); Ethanol: 60 mg/mL (201.13 mM); Water: Insoluble;
Molecular Weight
298.300 g/mol
XLogP3
3.300
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Rotatable Bond Count
3
Exact Mass
298.129 Da
Monoisotopic Mass
298.129 Da
Topological Polar Surface Area
32.299 Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
410.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
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