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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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M110918-50mg
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50mg |
2
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$9.90
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M110918-250mg
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250mg |
3
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$38.90
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M110918-1g
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1g |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$127.90
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M110918-5g
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5g |
3
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$576.90
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M110918-10g
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10g |
1
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$1,036.90
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M110918-25g
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25g |
2
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$2,332.90
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M110918-100g
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100g |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$8,398.90
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M110918-500g
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500g |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$37,791.90
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Immunosuppressant. Inosine monophosphate dehydrogenase inhibitor.
| Synonyms | (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid | DTXCID4028882 | DTXCID2021070 | Lilly 68618 | (4E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic Acid; Mycophen |
|---|---|
| Specifications & Purity | Moligand™, ≥98% |
| Biochemical and Physiological Mechanisms | Potent inosine monophosphate dehydrogenase inhibitor (IMPDH) (K i values are 11 and 6 nM at IMPDH type I and II, respectively). Decreases RNA and DNA synthesis. Immunosuppressive agent. Shows antiviral and antitumor effects in vitro and in vivo . |
| Storage Temp | Store at -20°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Isocoumarans |
| Subclass | Isobenzofuranones |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phthalides |
| Alternative Parents | Anisoles Medium-chain fatty acids Alkyl aryl ethers Methyl-branched fatty acids Hydroxy fatty acids Heterocyclic fatty acids Unsaturated fatty acids Dicarboxylic acids and derivatives Vinylogous acids Lactones Carboxylic acid esters Oxacyclic compounds Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Organic oxides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phthalide - Anisole - Medium-chain fatty acid - Alkyl aryl ether - Branched fatty acid - Methyl-branched fatty acid - Heterocyclic fatty acid - Hydroxy fatty acid - Dicarboxylic acid or derivatives - Fatty acyl - Fatty acid - Benzenoid - Unsaturated fatty acid - Vinylogous acid - Carboxylic acid ester - Lactone - Ether - Oxacycle - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organooxygen compound - Organic oxide - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as phthalides. These are compounds containing a 3-hydrocarbylidene-2-benzofuran-1(3H)-one moiety,. |
| External Descriptors | 2-benzofurans - monocarboxylic acid - phenols - gamma-lactone |
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| ALogP | 3.2 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504758856 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504758856 |
| IUPAC Name | (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid |
| INCHI | InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+ |
| InChIKey | HPNSFSBZBAHARI-RUDMXATFSA-N |
| Smiles | CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)O)O |
| Isomeric SMILES | CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O |
| WGK Germany | 3 |
| RTECS | MP8050000 |
| Molecular Weight | 320.34 |
| Beilstein | 1295848 |
| Reaxy-Rn | 8644904 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8644904&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Aug 31, 2024 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Sep 22, 2023 | M110918 | |
| Certificate of Analysis | Jun 05, 2023 | M110918 | |
| Certificate of Analysis | May 09, 2023 | M110918 | |
| Certificate of Analysis | May 09, 2023 | M110918 | |
| Certificate of Analysis | Sep 21, 2022 | M110918 |
| Solubility | Soluble in methanol at 50mg/ml |
|---|---|
| Sensitivity | Heat sensitive |
| Melt Point(°C) | 141-145℃ |
| Molecular Weight | 320.300 g/mol |
| XLogP3 | 3.200 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 6 |
| Exact Mass | 320.126 Da |
| Monoisotopic Mass | 320.126 Da |
| Topological Polar Surface Area | 93.100 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 485.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
| 1. Xiangli He, Jiayan Cui, Hui Ma, Naijipu Abuduaini, Ying Huang, Lu Tang, Wanyan Wang, Yuanyuan Zhang, Yang Wang, Weiqiang Lu, Bo Feng, Jin Huang. (2023) Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer. BIOCHEMICAL PHARMACOLOGY, 218 (115868). |
| 2. Lili Wu, Yulian Chen, Han Liu, Zhikun Zhan, Zhi Liang, Tao Zhang, Zheng Cai, Ling Ye, Menghua Liu, Jie Zhao, Shuwen Liu, Lan Tang. (2018) Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2. TOXICOLOGY AND APPLIED PHARMACOLOGY, 359 (91). |
| 3. Minhai Liu, Yan Zhang, Rui Cheng, Ting Tan, Lan Guo, Fan Liu, Yiqun Wan. (2025) Determination of five alternaria toxins in peppermint by dispersive solid-phase extraction coupled with ultra-high performance liquid chromatography-tandem mass spectrometry based on MOF-808-TFA. FOOD CHEMISTRY, 471 (142822). |
| 4. Xin Wang, Feiyang Pu, Xuanye Yang, Xili Feng, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiao-Xia Ma, Xiao-Ming Yang. (2024) Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition on nucleic acid synthesis, mRNA splicing and protein stability. Virulence, |