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MS9427 TFA - 99%, high purity , CAS No.M658914

COA

Grade & Purity:

≥99%

Molecular Weight: 1107.5

In stock

Item Number

M658914

Grouped product items
SKU	Size	Availability	Price	Qty
M658914-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$680.90
M658914-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,100.90

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EGFR (254) JAK/STAT Signaling (507) PROTAC (2077) PROTACs (183) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Specifications & Purity	≥99%
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	MS9427 TFA is a potent PROTAC EGFR degrader with K d s of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome Appearance:Solid In Vitro:MS9427 TFA has antiproliferative activity against HCC-827 cells, with a GI 50 of 0.87 ± 0.27 μM. MS9427 TFA (0-10 μM, 16 h) potently induces EGFR Del19 degradation (DC 50 =82 ± 73 nM) and inhibits EGFR phosphorylation (p-EGFR) in a concentration-depe Biological Activity:MS9427 TFA is a potent PROTAC EGFR degrader with K d s of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome

Names and Identifiers

Smiles	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(NCCOCCOCCOCCOCCOCCC(N4CCN(CCCOC5=CC6=C(NC7=CC=C(F)C(Cl)=C7)N=CN=C6C=C5OC)CC4)=O)=C3)=O.OC(C(F)(F)F)=O
Molecular Weight	1107.5

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