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MS9427 - 95%, high purity , CAS No.2772613-37-1

COA

Grade & Purity:

≥95%

Cas Number: 2772613-37-1
Molecular Weight: 993.47

In stock

Item Number

M650356

Grouped product items
SKU	Size	Availability	Price	Qty
M650356-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,100.90
M650356-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$680.90

View related series

EGFR (254) JAK/STAT Signaling (507) PROTAC (2077) PROTACs (183) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	MS9427 is a potent PROTAC EGFR degrader with K d s of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	MS9427 is a potent PROTAC EGFR degrader with K d s of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer In Vitro MS9427 has antiproliferative activity against HCC-827 cells, with a GI 50 of 0.87 ± 0.27 μM. MS9427 (0-10 μM, 16 h) potently induces EGFR Del19 degradation (DC 50 =82 ± 73 nM) and inhibits EGFR phosphorylation (p-EGFR) in a concentration-dependent manner in HCC-827 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HCC-827 cells Concentration: 1, 10, 50, 100, 200, 500, 100, and 10000 nM Incubation Time: 16 h Result: Inhibited EGFR phosphorylation (p-EGFR) in a concentration-dependent manner in HCC-827 cells. Western Blot AnalysisCell Line: HCC-827 cells Concentration: 100 nM Incubation Time: 1, 2, 4, 6, 12, 24, 48 h Result: Induced EGFR degradation in a time-dependent manner and through the UPS and autophagy/lysosome system. Form:Solid IC50& Target:EGFR (WT) 7.1 nM (Kd) EGFR L858R 4.3 nM (Kd)

Names and Identifiers

Smiles	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(NCCOCCOCCOCCOCCOCCC(N4CCN(CCCOC5=CC6=C(NC7=CC=C(F)C(Cl)=C7)N=CN=C6C=C5OC)CC4)=O)=C3)=O
Molecular Weight	993.47

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