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Product Description
MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 ( IC 50 =77 nM, AlphaLISA; 243 nM,
IC50& Target:IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP) Kd: 91 nM (SPIN1)
In Vitro:MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to
Biological Activity:MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 ( IC 50 =77 nM, AlphaLISA; 243 nM,
