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MPO-IN-1 - 99%, high purity , CAS No.2471981-21-0

COA

Grade & Purity:

≥99%

Cas Number: 2471981-21-0
Molecular Weight: 400.90

In stock

Item Number

M648657

Grouped product items
SKU	Size	Availability	Price
M648657-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
M648657-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
M648657-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,250.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase ( MPO ). MPO-IN-1 has IC 50 s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse mo
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase ( MPO ). MPO-IN-1 has IC 50 s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation In Vivo MPO-IN-1 (compound 2) (5 and 90 mg/kg; p.o.; four hours post-Zymosan A administration) significantly reduces MPO activity in a mouse peritonitis model of acute inflammation . Mouse pharmacokinetic parameter of MPO-IN-1 . Dose V ss (L/kg) T 1/2 (h) AUC inf (nM•h) p.o. C max (nM) p.o. PPB (%) F (%) 1/10 mg/kg i.v./p.o. 9.8 2.6 2486 502 99.6 61 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J mice (mouse peritonitis model of acute inflammation) Dosage: 5 and 90 mg/kg Administration: p.o. (four hours post-Zymosan A administration) Result: Resulted in a ~50% reduction in the MPO activity at 90 mg/kg. Form:Solid IC50& Target:2.6 μM (in plasma MPO assay),0.12 μM (in fluorescent MPO peroxidation assay)

Names and Identifiers

Smiles	ClC1=C(C(C2=CC3=C(C=CN3)C=C2)=CN4C5=CC=C(CN(C)C)C=C5)C4=NC=C1
Molecular Weight	400.90

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 200 mg/mL (498.88 mM; ultrasonic and warming and heat to 60°C)

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