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MMI-0100 - 99%, high purity , CAS No.1039342-24-9

1 Citations

COA

Grade & Purity:

≥99%

Cas Number: 1039342-24-9
Molecular Weight: 2283.64
PubChem CID: 127043567

In stock

Item Number

M650115

Grouped product items
SKU	Size	Availability	Price
M650115-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
M650115-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
M650115-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$950.90

View related series

MAPK/ERK Pathway (546) MAPKAPK2 (MK2) (12)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II ( MK2 ). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-010
Storage Temp	Protected from light,Argon charged,Desiccated,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II ( MK2 ). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease. In Vitro Naphthofluorescein (compound 19) (0-10 μM; 24 hours) suppresses the HIF-1 reporter activity in a concentration-dependent manner.. MMI-0100 (0.25 and 0.5 mM; 24 hours) slightly increases cell proliferation in both cell types compared to control cells treated with 20 ng/ml TNF-α alone. MMI-0100 (1 mM) treatment also increases both EC (11%) and SMC (7%) proliferation as compared to control, this response is not as robust as that induced by treatment with 0.5 mM MMI-0100. MMI-0100 does not induce EC apoptosis at any dose. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: human endothelial cell (EC) and smooth muscle cell (SMC) Concentration: 0.25, 0.5, and 1 mM Incubation Time: 24 hours Result: Slightly increased cell proliferation in both cell types compared to control cells. In Vivo MMI-0100 (100 μM; 28 days) inhibits intimal hyperplasia in a mouse vein graft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-week-old C57Bl/6 wild type mice (intimal hyperplasia) Dosage: 100 μM Administration: vein graft, 28 days Result: Diminished wall thickness at all postoperative time points in vein grafts treated with MMI-0100, with a ratio of 2.6-fold thicker at 4 weeks, compared to 4.7-fold thicker at 4 weeks in control grafts. Form:Solid

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Smiles	C[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(C=C1)O)N
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(C=C1)O)N
PubChem CID	127043567
Molecular Weight	2283.64

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