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MLT-748 - 99%, high purity , CAS No.1832578-30-9

COA

Grade & Purity:

≥99%

Cas Number: 1832578-30-9
Molecular Weight: 492.32
PubChem CID: 129072285

In stock

Item Number

M414254

Grouped product items
SKU	Size	Availability	Price
M414254-1mg	1mg	3	$93.90
M414254-5mg	5mg	3	$282.90
M414254-10mg	10mg	3	$456.90
M414254-25mg	25mg	2	$699.90

MALT Inhibitors

View related series

Amino Acid/Protein Metabolism (1836) MALT1 (15) Metabolic Enzyme/Protease (4860) NF-κB (747)

Basic Description

Synonyms	Urea,N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state. Targets MALT1 (Cell-free assay) 5 nM In vitro MLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1^mut/mut lymphocytes. Cell Research(from reference) Cell lines：Immortalized B cells, human PBMCs, primary human CD3+ T cells, primary CD4+ lymphocytes Concentrations：2 μM Incubation Time：24 h

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Pyridyltriazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Pyridyltriazoles
Intermediate Tree Nodes	Not available
Direct Parent	Pyridyl-1,2,3-triazoles
Alternative Parents	Pyrazolo[1,5-a]pyrimidines Pyrimidines and pyrimidine derivatives Aryl chlorides Triazoles Pyrazoles Heteroaromatic compounds Ureas Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyridyl-1,2,3-triazole - Pyrazolo[1,5-a]pyrimidine - Pyrazolopyrimidine - Pyrimidine - Aryl halide - Aryl chloride - Heteroaromatic compound - 1,2,3-triazole - Triazole - Pyrazole - Azole - Urea - Carbonic acid derivative - Azacycle - Ether - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyridyl-1,2,3-triazoles. These are organic compounds containing a pyridine ring attached to a 1,2,3-triazole ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	1-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]urea
INCHI	InChI=1S/C19H19Cl2N9O3/c1-10(32-2)17(33-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t10-,17+/m1/s1
InChIKey	XKQLNDPUQSZBJW-QGHHPUGFSA-N
Smiles	CC(C(C1=C(C=NC2=CC(=NN21)Cl)NC(=O)NC3=CC(=C(N=C3)N4N=CC=N4)Cl)OC)OC
PubChem CID	129072285
Molecular Weight	492.32

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
G2416495	Certificate of Analysis	Mar 25, 2024	M414254
G2416447	Certificate of Analysis	Mar 25, 2024	M414254
G2416490	Certificate of Analysis	Mar 25, 2024	M414254
G2416492	Certificate of Analysis	Mar 25, 2024	M414254
G2416493	Certificate of Analysis	Mar 25, 2024	M414254
G2416494	Certificate of Analysis	Mar 25, 2024	M414254
G2416462	Certificate of Analysis	Mar 25, 2024	M414254
G2416475	Certificate of Analysis	Mar 25, 2024	M414254

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 98 mg/mL (199.05 mM); Ethanol: 10 mg/mL (20.31 mM); Water: Insoluble;
Molecular Weight	492.300 g/mol
XLogP3	1.700
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	491.099 Da
Monoisotopic Mass	491.099 Da
Topological Polar Surface Area	133.000 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	662.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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