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MLN4924 - ≥98%, high purity , NEDD8 activating enzyme inhibitor, CAS No.905579-51-3, NEDD8 activating enzyme inhibitor

1 Citations COA COA
In stock
Item Number
M127498
Grouped product items
SKU Size
Availability
 Price Qty
M127498-1mg
1mg
5
$39.90
M127498-5mg
5mg
3
$89.90
M127498-10mg
10mg
2
$139.90
M127498-25mg
25mg
2
$269.90
M127498-50mg
50mg
1
$446.90
M127498-100mg
100mg
1
$717.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent, selective NEDD8-activating enzyme inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Metabolic Enzyme/Protease (4860) NEDD8-activating Enzyme (9)

Basic Description

Synonyms Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester | Pevonedistat
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms MLN4924 (MLN-4924)is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action NEDD8 activating enzyme inhibitor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Indanes
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Indanes
Alternative Parents Pyrrolo[2,3-d]pyrimidines  Secondary alkylarylamines  Aminopyrimidines and derivatives  Substituted pyrroles  Imidolactams  Cyclopentanols  Organic sulfuric acids and derivatives  Heteroaromatic compounds  Cyclic alcohols and derivatives  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Pyrrolo[2,3-d]pyrimidine - Indane - Pyrrolopyrimidine - Aminopyrimidine - Secondary aliphatic/aromatic amine - Cyclopentanol - Pyrimidine - Imidolactam - Substituted pyrrole - Cyclic alcohol - Organic sulfuric acid or derivatives - Heteroaromatic compound - Pyrrole - Secondary alcohol - Secondary amine - Organoheterocyclic compound - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Alcohol - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as indanes. These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring.
External Descriptors Not available

Product Properties

ALogP 1.7

Associated Targets(Human)

NEDD8 Tchem NEDD8 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
UBA3 Tchem NEDD8-activating enzyme E1 catalytic subunit (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
NAE1 Tchem NEDD8-activating enzyme E1 regulatory subunit (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDM2 Tchem p53-binding protein Mdm-2 (4545 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caco-2 (12174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAPAN-1 (772 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Huh-7 (12904 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HuTu80 (255 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MKN-45 (2102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLC (23 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RKO (1376 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THP-1 (11052 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T47D (39041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EKVX (44102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H1299 (3248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Jurkat (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MV4-11 (7307 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TAOK1 Tchem Serine/threonine-protein kinase TAO1 (2019 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UBA1 Tbio Ubiquitin-like modifier-activating enzyme 1 (57 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HGC-27 (1452 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UBA5 Tbio Ubiquitin-like modifier-activating enzyme 5 (22 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UBA3 Tchem NEDD8-activating enzyme E1 catalytic subunit (128 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NAE1 Tchem NEDD8-activating enzyme E1 regulatory subunit (121 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SAE1 Tbio SUMO-activating enzyme (861 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATG7 Tchem Ubiquitin-like modifier-activating enzyme ATG7 (562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UBA6 Tchem Ubiquitin-like modifier-activating enzyme 6 (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LNCaP-Clone-FGC (157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MGC-803 (6426 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CUL1 Tbio Cullin-1 (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UBA3 Tchem NEDD8 activating enzyme (447 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DCUN1D1 Tchem DCN1-like protein 1 (571 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NEDD8 Tchem NEDD8 (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BEAS-2B (690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GES1 (603 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CUL4B Tbio Cullin-4B (16 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DCUN1D1 Tchem DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 (236 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CUL1 Tbio NEDD8/Cullin-1 (16 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CUL5 Tbio Cullin-5 (5 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cul4a Cullin-4A (23 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488199412
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488199412
IUPAC Name [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate
INCHI InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
InChIKey MPUQHZXIXSTTDU-QXGSTGNESA-N
Smiles C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N
Isomeric SMILES C1CC2=CC=CC=C2[C@H]1NC3=C4C=CN(C4=NC=N3)[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
Molecular Weight 443.53
Reaxy-Rn 23228808
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23228808&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot Number Certificate Type Date Item
D2327142 Certificate of Analysis Feb 07, 2025 M127498
D2327134 Certificate of Analysis Feb 07, 2025 M127498
D2327141 Certificate of Analysis Feb 07, 2025 M127498
D2327138 Certificate of Analysis Feb 07, 2025 M127498
D2327144 Certificate of Analysis Feb 07, 2025 M127498
D2327145 Certificate of Analysis Feb 07, 2025 M127498
D2327146 Certificate of Analysis Feb 07, 2025 M127498
D2327149 Certificate of Analysis Feb 07, 2025 M127498
D2327147 Certificate of Analysis Feb 07, 2025 M127498
D2327150 Certificate of Analysis Feb 07, 2025 M127498
J2431419 Certificate of Analysis Oct 22, 2024 M127498
J2431420 Certificate of Analysis Oct 22, 2024 M127498
J2431421 Certificate of Analysis Oct 22, 2024 M127498
J2431423 Certificate of Analysis Oct 22, 2024 M127498
J2431422 Certificate of Analysis Oct 22, 2024 M127498
D2526068 Certificate of Analysis Oct 22, 2024 M127498
D2327140 Certificate of Analysis Apr 21, 2023 M127498
D2327143 Certificate of Analysis Apr 21, 2023 M127498

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Chemical and Physical Properties

Solubility DMSO (Slightly), Methanol (Slightly)
Sensitivity Moisture sensitive
Melt Point(°C) 98°C
Molecular Weight 443.500 g/mol
XLogP3 1.700
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 6
Exact Mass 443.163 Da
Monoisotopic Mass 443.163 Da
Topological Polar Surface Area 141.000 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 734.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. Pevonedistat (MLN4924), NEDD8 activating enzyme inhibitor
    Pevonedistat (MLN4924), NEDD8 activating enzyme inhibitor

    Starting at $91.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li.  (2024)  A potent GPX4 degrader to induce ferroptosis in HT1080 cells.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,  265  (116110). 

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