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ML204 hydrochloride - 99%, high purity , CAS No.2070015-10-8

COA

Grade & Purity:

≥99%

Cas Number: 2070015-10-8
Molecular Weight: 262.78
PubChem CID: 49786978

In stock

Item Number

M649192

Grouped product items
SKU	Size	Availability	Price
M649192-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$50.90
M649192-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$80.90
M649192-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
M649192-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$280.90

View related series

Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) TRP Channel (181)

Basic Description

Synonyms	4-Methyl-2-(piperidin-1-yl)quinoline hydrochloride \| ML204 HCl \| AKOS032945007 \| ML204 hydrochloride \| ML 204 HCl; ML204 hydrochloride; ML 204 hydrochloride; ML-204 hydrochloride \| MLS003227299 \| BS-15926 \| HY-12949A \| ML204hydrochloride \| 4-methyl-2-pipe
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels In Vitro ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca 2+ rise with an IC 50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. ML204 hydrochloride blocks TRPC4β activity induced through either G i/o stimulation by μ-opioid, 5HT 1A serotonin, and M 2 muscarinic receptors or G q/11 stimulation by the endogenous M 3 -like muscarinic receptors. ML204 hydrochloride blocks LPS-induced TRPC5 channel activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nonfasted male C57BL/6 (2-3 months)Dosage: 1 mg/kg Administration: Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) Result: Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response. Form:Solid IC50& Target:TRPC4\|TRPC5

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Aminoquinolines and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Aminoquinolines and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Aminoquinolines and derivatives
Alternative Parents	Dialkylarylamines Methylpyridines Aminopyridines and derivatives Piperidines Imidolactams Benzenoids Heteroaromatic compounds Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Aminoquinoline - Dialkylarylamine - Aminopyridine - Methylpyridine - Piperidine - Pyridine - Imidolactam - Benzenoid - Heteroaromatic compound - Tertiary amine - Azacycle - Amine - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	4-methyl-2-piperidin-1-ylquinoline;hydrochloride
INCHI	InChI=1S/C15H18N2.ClH/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14;/h3-4,7-8,11H,2,5-6,9-10H2,1H3;1H
InChIKey	QCABWRXQHZUBPW-UHFFFAOYSA-N
Smiles	CC1=CC(=NC2=CC=CC=C12)N3CCCCC3.Cl
Isomeric SMILES	CC1=CC(=NC2=CC=CC=C12)N3CCCCC3.Cl
Alternate CAS	2070015-10-8
PubChem CID	49786978
MeSH Entry Terms	ML 204;ML-204;ML204 cpd
Molecular Weight	262.78

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	H2O : ≥ 30 mg/mL (114.16 mM)
Molecular Weight	262.780 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	262.124 Da
Monoisotopic Mass	262.124 Da
Topological Polar Surface Area	16.100 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	247.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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