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ML 265 - 98%, high purity , CAS No.1221186-53-3, Activator of pyruvate kinase M1/2

COA COA
In stock
Item Number
M333473
Grouped product items
SKU Size
Availability
 Price Qty
M333473-5mg
5mg
3
$117.90
M333473-10mg
10mg
3
$177.90
M333473-25mg
25mg
2
$400.90
M333473-50mg
50mg
2
$533.90
M333473-100mg
100mg
2
$771.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

an activator of PKM2.

View related series
Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) Pyruvate Kinase (17) pyruvate kinase M1/2 Activator (4)

Basic Description

Synonyms AS-16621 | MLS006010294 | A901578 | [6-(3-Aminobenzyl)-4-methyl-5-oxo-5,6-dihydro-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-2-yl](methyl)sulfoniumolate | DB01996 | FT-0663861 | 2-METHYLPYRIDINE [HSDB] | 4-methyl morpholine | ML265 | ML-265 | SMR00470136
Specifications & Purity Moligand™, ≥98%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type ACTIVATOR
Mechanism of action Activator of pyruvate kinase M1/2

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Thienopyrroles
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Thienopyrroles
Alternative Parents Aniline and substituted anilines  2,3,5-trisubstituted thiophenes  Pyridazinones  N-methylpyrroles  Heteroaromatic compounds  Sulfoxides  Lactams  Sulfinyl compounds  Azacyclic compounds  Primary amines  Organopnictogen compounds  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Aniline or substituted anilines - 2,3,5-trisubstituted thiophene - Thienopyrrole - Pyridazinone - Monocyclic benzene moiety - N-methylpyrrole - Pyridazine - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Thiophene - Lactam - Sulfoxide - Azacycle - Sulfinyl compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as thienopyrroles. These are heterocyclic compounds containing a thiophene ring fused to a pyrrole ring. Thiophene is 5-membered ring consisting of four carbon atoms and one sulfur atom. Pyrrole is 5-membered ring consisting of four carbon atoms and one nitrogen atom.
External Descriptors Not available

Associated Targets(Human)

PKM Tchem Pyruvate kinase PKM (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-126 (160 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW480 (6023 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-251 (51189 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-87 MG (3946 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-118-MG (352 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pklr Pyruvate kinase isozymes R/L (113 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
C6 (2371 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488200983
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488200983
IUPAC Name 10-[(3-aminophenyl)methyl]-7-methyl-4-methylsulfinyl-3-thia-7,10,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),4,11-tetraen-9-one
INCHI InChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3
InChIKey ZWKJWVSEDISQIS-UHFFFAOYSA-N
Smiles CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C
Isomeric SMILES CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C
Molecular Weight 372.5
Reaxy-Rn 20138466
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20138466&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
D2312465 Certificate of Analysis Feb 28, 2023 M333473
D2312468 Certificate of Analysis Feb 28, 2023 M333473
D2312469 Certificate of Analysis Feb 28, 2023 M333473
D2312464 Certificate of Analysis Feb 28, 2023 M333473
D2312552 Certificate of Analysis Feb 28, 2023 M333473
D2312467 Certificate of Analysis Feb 28, 2023 M333473
D2312462 Certificate of Analysis Feb 28, 2023 M333473
D2312470 Certificate of Analysis Feb 28, 2023 M333473
D2312471 Certificate of Analysis Feb 28, 2023 M333473
D2312472 Certificate of Analysis Feb 28, 2023 M333473

Chemical and Physical Properties

Solubility Soluble in DMSO (~10 mg/ml).
Refractive Index n20D1.81 (Predicted)
Boil Point(°C) ~711.6° C at 760 mmHg (Predicted)
Molecular Weight 372.500 g/mol
XLogP3 1.300
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 3
Exact Mass 372.071 Da
Monoisotopic Mass 372.071 Da
Topological Polar Surface Area 128.000 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 601.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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