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p97
ML 240 - ≥99%(HPLC), high purity , CAS No.1346527-98-7

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ML 240 - ≥99%(HPLC), high purity , CAS No.1346527-98-7

COA

Grade & Purity:

≥99%(HPLC)

Cas Number: 1346527-98-7
Molecular Weight: 396.44
PubChem CID: 49830258

In stock

Item Number

M287304

Grouped product items
SKU	Size	Availability	Price
M287304-5mg	5mg	2	$90.90
M287304-10mg	10mg	2	$142.90
M287304-25mg	25mg	2	$299.90
M287304-50mg	50mg	2	$521.90
M287304-100mg	100mg	2	$913.90

ATP-competitive inhibitor of p97 ATPase

View related series

Cell Cycle/DNA Damage (2602) DNA Damage (697) p97 (13)

Basic Description

Synonyms	BCP25527 \| NCGC00347064-07 \| SCHEMBL12134616 \| KSC-206-032 \| Tris(beta-Methoxyethoxy)vinylsilane \| AC-36234 \| NCGC00347064-04 \| SMR002239184 \| MLS003568129 \| CID-49830258 \| 2-(2-amino-1H-1,3-benzodiazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine \| 2-(2-am
Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	ATP-competitive inhibitor of p97 ATPase (VCP, IC50= 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autop
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Application ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazanaphthalenes
    - Subclass Benzodiazines
      - Level5 Quinazolines
        Level6 Quinazolinamines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazanaphthalenes
Subclass	Benzodiazines
Intermediate Tree Nodes	Quinazolines
Direct Parent	Quinazolinamines
Alternative Parents	Benzimidazoles Benzylamines Anisoles Aminopyrimidines and derivatives Alkyl aryl ethers N-substituted imidazoles Imidolactams Aminoimidazoles Heteroaromatic compounds Azacyclic compounds Primary amines Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinazolinamine - Benzimidazole - Anisole - Phenol ether - Benzylamine - Alkyl aryl ether - Aminopyrimidine - Aminoimidazole - Monocyclic benzene moiety - Imidolactam - Benzenoid - Pyrimidine - N-substituted imidazole - Heteroaromatic compound - Azole - Imidazole - Azacycle - Ether - Organooxygen compound - Primary amine - Amine - Organic nitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

VCP Tchem Transitional endoplasmic reticulum ATPase (2 Activities)

Discover Target: VCP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VCP Tchem Transitional endoplasmic reticulum ATPase (895 Activities)

Discover Target: VCP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-(2-aminobenzimidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine
INCHI	InChI=1S/C23H20N6O/c1-30-19-13-7-10-16-20(19)27-23(28-21(16)25-14-15-8-3-2-4-9-15)29-18-12-6-5-11-17(18)26-22(29)24/h2-13H,14H2,1H3,(H2,24,26)(H,25,27,28)
InChIKey	NHAMBLRUUJAFOY-UHFFFAOYSA-N
Smiles	COC1=CC=CC2=C1N=C(N=C2NCC3=CC=CC=C3)N4C5=CC=CC=C5N=C4N
Isomeric SMILES	COC1=CC=CC2=C1N=C(N=C2NCC3=CC=CC=C3)N4C5=CC=CC=C5N=C4N
Molecular Weight	396.44
Reaxy-Rn	24899602
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24899602&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
K2229776	Certificate of Analysis	Oct 20, 2022	M287304
K2229779	Certificate of Analysis	Oct 20, 2022	M287304
K2229782	Certificate of Analysis	Oct 20, 2022	M287304
K2229784	Certificate of Analysis	Oct 20, 2022	M287304
K2229783	Certificate of Analysis	Oct 20, 2022	M287304

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 7.93, Max Conc. mM: 20
Molecular Weight	396.400 g/mol
XLogP3	4.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	396.17 Da
Monoisotopic Mass	396.17 Da
Topological Polar Surface Area	90.900 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	558.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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ML 240 - ≥99%(HPLC), high purity , CAS No.1346527-98-7

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

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