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ML 228 - ≥98%(HPLC), high purity , CAS No.1357171-62-0

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
M288029
Grouped product items
SKU Size
Availability
 Price Qty
M288029-5mg
5mg
3
$107.90
M288029-10mg
10mg
2
$197.90
M288029-25mg
25mg
1
$445.90
M288029-50mg
50mg
1
$854.90
M288029-100mg
100mg
1
$1,282.90
M288029-200mg
200mg
1
$2,309.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

HIF pathway activator

View related series
Glucose Metabolism (1943) HIF/HIF Prolyl-Hydroxylase (128) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine | CID-46742353
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms HIF pathway activator (EC50values are 1.23 and 1.4μM for HRE gene reporter assay and HIF-1αnuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3receptor, dopamine transp
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Biphenyls and derivatives
Intermediate Tree Nodes Not available
Direct Parent Biphenyls and derivatives
Alternative Parents Benzylamines  Secondary alkylarylamines  Pyridines and derivatives  Imidolactams  1,2,4-triazines  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Biphenyl - Benzylamine - Secondary aliphatic/aromatic amine - Pyridine - 1,2,4-triazine - Triazine - Imidolactam - Heteroaromatic compound - Azacycle - Secondary amine - Organoheterocyclic compound - Hydrocarbon derivative - Organonitrogen compound - Organopnictogen compound - Amine - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors Not available

Associated Targets(Human)

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGER4 Tclin Prostanoid EP4 receptor (2181 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488201356
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488201356
IUPAC Name 6-phenyl-N-[(4-phenylphenyl)methyl]-3-pyridin-2-yl-1,2,4-triazin-5-amine
INCHI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
InChIKey QNRODODTMXCRKU-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=C(N=NC(=N3)C4=CC=CC=N4)C5=CC=CC=C5
Isomeric SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=C(N=NC(=N3)C4=CC=CC=N4)C5=CC=CC=C5
Molecular Weight 415.49
Reaxy-Rn 22196087
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22196087&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number Certificate Type Date Item
C23181153 Certificate of Analysis Dec 17, 2022 M288029
C23181392 Certificate of Analysis Dec 17, 2022 M288029
C23181393 Certificate of Analysis Dec 17, 2022 M288029
C23181349 Certificate of Analysis Dec 17, 2022 M288029
C23181353 Certificate of Analysis Dec 17, 2022 M288029
C23181354 Certificate of Analysis Dec 17, 2022 M288029
C23181355 Certificate of Analysis Dec 17, 2022 M288029
C23181356 Certificate of Analysis Dec 17, 2022 M288029
C23181351 Certificate of Analysis Dec 17, 2022 M288029
C23181357 Certificate of Analysis Dec 17, 2022 M288029
C23181359 Certificate of Analysis Dec 17, 2022 M288029
C23181227 Certificate of Analysis Dec 17, 2022 M288029

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Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 41.55, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 8.31, Max Conc. mM: 20
Molecular Weight 415.500 g/mol
XLogP3 4.900
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 6
Exact Mass 415.18 Da
Monoisotopic Mass 415.18 Da
Topological Polar Surface Area 63.600 Ų
Heavy Atom Count 32
Formal Charge 0
Complexity 536.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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