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MKC-1 - 99%, high purity , Platelet-derived growth factor receptor inhibitor, CAS No.125313-92-0, Platelet-derived growth factor receptor inhibitor

COA

Grade & Purity:

≥98%

Cas Number: 125313-92-0
Molecular Weight: 400.39
PubChem CID: 5327686

In stock

Item Number

M648876

Grouped product items
SKU	Size	Availability	Price
M648876-1mg	1mg	3	$39.90
M648876-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
M648876-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$169.90
M648876-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$289.90
M648876-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
M648876-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$559.90

View related series

Akt (180) Apoptosis (4276) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Cytoskeleton (498) Microtubule protein (1) Microtubule/Tubulin (199) mTOR (145) PI3K/Akt/mTOR (765)

Basic Description

Synonyms	R 440 \| DNZ11VPY7Q \| AKOS030228212 \| BDBM2622 \| Ro-31-7453 \| Piromelatine \| NEU-P-11 \| Piromelatine [INN] \| NEU-P11
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins incl
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Platelet-derived growth factor receptor inhibitor
Product Description	MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass N-alkylindoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	N-alkylindoles
Intermediate Tree Nodes	Not available
Direct Parent	N-alkylindoles
Alternative Parents	Indoles Nitroaromatic compounds Maleimides Benzenoids N-methylpyrroles Pyrrolines Dicarboximides Heteroaromatic compounds N-unsubstituted carboxylic acid imides Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organic oxoazanium compounds Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Organonitrogen compounds Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-alkylindole - Indole - Nitroaromatic compound - Maleimide - N-methylpyrrole - Substituted pyrrole - Benzenoid - Carboxylic acid imide - Dicarboximide - Carboxylic acid imide, n-unsubstituted - Pyrrole - Pyrroline - Heteroaromatic compound - Organic nitro compound - C-nitro compound - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Carboxylic acid derivative - Organic oxoazanium - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Organopnictogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-(1-methylindol-3-yl)-4-(1-methyl-6-nitroindol-3-yl)pyrrole-2,5-dione
INCHI	InChI=1S/C22H16N4O4/c1-24-10-15(13-5-3-4-6-17(13)24)19-20(22(28)23-21(19)27)16-11-25(2)18-9-12(26(29)30)7-8-14(16)18/h3-11H,1-2H3,(H,23,27,28)
InChIKey	OVSKGTONMLKNPZ-UHFFFAOYSA-N
Smiles	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=C4C=CC(=C5)[N+](=O)[O-])C
Isomeric SMILES	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=C4C=CC(=C5)[N+](=O)[O-])C
PubChem CID	5327686
Molecular Weight	400.39

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
J2411581	Certificate of Analysis	Jul 24, 2024	M648876
J2411583	Certificate of Analysis	Jul 24, 2024	M648876
J2411769	Certificate of Analysis	Jul 24, 2024	M648876
J2411771	Certificate of Analysis	Jul 24, 2024	M648876
J2411773	Certificate of Analysis	Jul 24, 2024	M648876
J2411580	Certificate of Analysis	Jul 24, 2024	M648876
J2411577	Certificate of Analysis	Jul 24, 2024	M648876
J2411582	Certificate of Analysis	Jul 24, 2024	M648876
J2411584	Certificate of Analysis	Jul 24, 2024	M648876
J2411579	Certificate of Analysis	Jul 24, 2024	M648876
J2411585	Certificate of Analysis	Jul 24, 2024	M648876
J2411578	Certificate of Analysis	Jul 24, 2024	M648876

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Chemical and Physical Properties

Solubility	DMSO : ≥ 50 mg/mL (124.88 mM)
Molecular Weight	400.400 g/mol
XLogP3	2.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	400.117 Da
Monoisotopic Mass	400.117 Da
Topological Polar Surface Area	102.000 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	805.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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