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MK6-83 - ≥98%(HPLC), high purity , CAS No.1062271-24-2, Activator of TRPML1;Activator of TRPML3

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 1062271-24-2
Molecular Weight: 336.47
PubChem CID: 18191179
PubChem SID: 504768682

In stock

Item Number

M288781

Grouped product items
SKU	Size	Availability	Price
M288781-1mg	1mg	3	$19.90
M288781-5mg	5mg	3	$81.90
M288781-10mg	10mg	2	$118.90
M288781-25mg	25mg	2	$244.90
M288781-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$412.90

TRPML channel activator

View related series

Ion channel (2197) Membrane Transporter/Ion Channel (1822) Neuronal Signaling (3320) TRP Channel (181) TRPML1 Activator (7) TRPML3 Activator (10)

Basic Description

Synonyms	AKOS025147398 \| MK683 \| MK6-83 \| 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide \| 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)- \| GTPL9783 \| s6947 \| NCGC00402264-04 \| 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	TRPML channel activator (EC50= 110 nM). Also activates F408Δand F465L TRPML mutants (EC50values are 0.1 and 1.23μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.MK6-8
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of TRPML1;Activator of TRPML3

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Piperidines
    - Subclass Phenylpiperidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Piperidines
Subclass	Phenylpiperidines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpiperidines
Alternative Parents	Sulfanilides Dialkylarylamines Aniline and substituted anilines 2,5-disubstituted thiophenes Organosulfonamides Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Phenylpiperidine - Sulfanilide - Tertiary aliphatic/aromatic amine - Aniline or substituted anilines - Dialkylarylamine - 2,5-disubstituted thiophene - Monocyclic benzene moiety - Organosulfonic acid amide - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Thiophene - Aminosulfonyl compound - Heteroaromatic compound - Tertiary amine - Azacycle - Organic nitrogen compound - Organic oxide - Amine - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organosulfur compound - Organic oxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MCOLN1 Tchem Mucolipin-1 (2 Activities)

Discover Target: MCOLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MCOLN3 Tchem Mucolipin-3 (0 Activities)

Discover Target: MCOLN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504768682
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504768682
IUPAC Name	5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide
INCHI	InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
InChIKey	IRGYSXZCDAWOOC-UHFFFAOYSA-N
Smiles	CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
Isomeric SMILES	CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
Molecular Weight	336.47
Reaxy-Rn	41646062
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=41646062&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
J2129948	Certificate of Analysis	Aug 14, 2024	M288781
J2130108	Certificate of Analysis	Aug 14, 2024	M288781
J2130109	Certificate of Analysis	Aug 14, 2024	M288781
J2130110	Certificate of Analysis	Aug 14, 2024	M288781
J2130111	Certificate of Analysis	Aug 14, 2024	M288781

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 33.65, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 6.73, Max Conc. mM: 20
Molecular Weight	336.500 g/mol
XLogP3	3.800
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	336.097 Da
Monoisotopic Mass	336.097 Da
Topological Polar Surface Area	86.000 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	457.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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