Skip to the beginning of the images gallery

MK 212 hydrochloride - ≥99%, high purity , CAS No.61655-58-1

COA

Grade & Purity:

≥99%

Cas Number: 61655-58-1
Molecular Weight: 235.11
PubChem CID: 198421
PubChem SID: 488188590

In stock

Item Number

M276020

Grouped product items
SKU	Size	Availability	Price
M276020-10mg	10mg	5	$109.90
M276020-50mg	50mg	5	$465.90
M276020-100mg	100mg	4	$837.90
M276020-250mg	250mg	3	$1,885.90
M276020-1g	1g	2	$6,786.90

Potent, selective 5-HT 2C receptor agonist

View related series

Class A GPCR (4138)

Basic Description

Synonyms	MK-212 HCl \| T0294 \| Q27269784 \| PFIZGLUIYAZQFU-UHFFFAOYSA-N \| DTXSID60210668 \| PYRAZINE, 2-CHLORO-6-(1-PIPERAZINYL)-, HYDROCHLORIDE (1:1) \| FT-0759415 \| 2-Chloro-6-(1-piperazinyl)pyrazine monohydrochloride \| MK-212 (monohydrochloride) \| MK212HCl \| MK-212
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Potent, selective 5-HT 2C receptor agonist (IC 50 values are 28 and 420 nM for 5-HT 2C and 5-HT 2A receptors, respectively). Shows anxiogenic effects and decreases locomotor activity in vivo.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product description： MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazinanes
    - Subclass Piperazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazinanes
Subclass	Piperazines
Intermediate Tree Nodes	Not available
Direct Parent	N-arylpiperazines
Alternative Parents	Dialkylarylamines Aminopyrazines Imidolactams Aryl chlorides Heteroaromatic compounds Dialkylamines Azacyclic compounds Organopnictogen compounds Organochlorides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	N-arylpiperazine - Dialkylarylamine - Aminopyrazine - Aryl chloride - Aryl halide - Pyrazine - Imidolactam - Heteroaromatic compound - Secondary aliphatic amine - Azacycle - Secondary amine - Organonitrogen compound - Organochloride - Organohalogen compound - Amine - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488188590
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488188590
IUPAC Name	2-chloro-6-piperazin-1-ylpyrazine;hydrochloride
INCHI	InChI=1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H
InChIKey	PFIZGLUIYAZQFU-UHFFFAOYSA-N
Smiles	C1CN(CCN1)C2=CN=CC(=N2)Cl.Cl
Isomeric SMILES	C1CN(CCN1)C2=CN=CC(=N2)Cl.Cl
WGK Germany	3
PubChem CID	198421
Molecular Weight	235.11

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
F2516095	Certificate of Analysis	Jul 04, 2025	M276020
D2301632	Certificate of Analysis	Jan 15, 2024	M276020
D2301622	Certificate of Analysis	Jan 15, 2024	M276020
D2301617	Certificate of Analysis	Jan 15, 2024	M276020
D2301615	Certificate of Analysis	Jan 15, 2024	M276020
D2301614	Certificate of Analysis	Jan 15, 2024	M276020
D2301620	Certificate of Analysis	Jan 12, 2024	M276020
D2301611	Certificate of Analysis	Jan 12, 2024	M276020
D2301621	Certificate of Analysis	Jan 03, 2024	M276020
D2301619	Certificate of Analysis	Jan 03, 2024	M276020
D2301618	Certificate of Analysis	Jan 03, 2024	M276020

Show more⌵

Chemical and Physical Properties

Solubility	Soluble in water to 50 mM
Molecular Weight	235.110 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	234.044 Da
Monoisotopic Mass	234.044 Da
Topological Polar Surface Area	41.100 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	160.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration